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Modulation of the Hydration Water Around Monoclonal Antibodies on Addition of Excipients Detected by Terahertz Time-Domain Spectroscopy.

Vincent P Wallace, Denis Ferachou, Peng Ke, Katie Day, Shahid Uddin, Jose Casas-Finet, Christopher F Van Der Walle, Robert J Falconer, J Axel Zeitler

OAI: oai:www.repository.cam.ac.uk:1810/250488

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Abstract

analytical biochemistry Arginine formulation hydration layer Monoclonal antibody protein aggregation protein formulation Stability Terahertz Spectroscopy Antibodies Monoclonal Arginine Chemistry Pharmaceutical excipients Solutions Sucrose Terahertz Spectroscopy water