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Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability.

Matthew J Edgeworth, Jonathan J Phillips, David C Lowe, Alistair D Kippen, Daniel R Higazi, James H Scrivens

OAI: oai:www.repository.cam.ac.uk:1810/251192

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Abstract

Antibodies hydrogen exchange immunoglobulin ion mobility Mass Spectrometry Antibodies Monoclonal Deuterium Exchange Measurement Humans Immunoglobulin G Mass Spectrometry Protein Conformation Thermodynamics