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Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency.
Monica Ceccon, Maria Elena Boggio Merlo, Luca Mologni, Teresa Poggio, Lydia M Varesio, Matteo Menotti, Silvia Bombelli, Roberta Rigolio, Andrea D Manazza, Filomena Di Giacomo, Chiara Ambrogio, Giovanni Giudici, Cesare Casati, Cristina Mastini, Mara Compagno, Suzanne D Turner, Carlo Gambacorti-Passerini, Roberto Chiarle, Claudia Voena
OAI: oai:www.repository.cam.ac.uk:1810/253157
Abstract
Animals Apoptosis Blotting Western Cell Line Tumor Cell Survival Cells Cultured Crizotinib Dose-Response Relationship Drug Drug Synergism Extracellular Signal-Regulated MAP Kinases Histones Humans Hydrazines Lymphoma Large-Cell Anaplastic Mice Inbred NOD Mice Knockout Mice SCID Microscopy Confocal Nucleophosmin Oncogene Proteins Fusion Protein Kinase Inhibitors Protein-Tyrosine Kinases Pyrazoles Pyridines RNA Interference Signal Transduction Transplantation Heterologous Triazoles