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Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo.
Kenneth A Botkjaer
,
Hang Fai Kwok
,
Mikkel G Terp
,
Aneesh Karatt-Vellatt
,
Salvatore Santamaria
,
John McCafferty
,
Peter A Andreasen
,
Yoshifumi Itoh
,
Henrik J Ditzel
,
Gillian Murphy
OAI: oai:www.repository.cam.ac.uk:1810/254526
Published by:
Abstract
MT1-MMP
Antibody
in vivo targeting
metastasis
non-catalytic sites
Animals
Antibody Affinity
Antineoplastic Agents
Cell Line
Tumor
Humans
Matrix Metalloproteinase 14
Mice
Mice
SCID
Neoplasm Invasiveness
Single-Chain Antibodies
Xenograft Model Antitumor Assays