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Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers

KB Kuchenbaecker, L McGuffog, D Barrowdale, A Lee, P Soucy, J Dennis, SM Domchek, M Robson, AB Spurdle, SJ Ramus, N Mavaddat, MB Terry, SL Neuhausen, RK Schmutzler, J Simard, PDP Pharoah, K Offit, FJ Couch, G Chenevix-Trench, DF Easton, AC Antoniou

OAI: oai:www.repository.cam.ac.uk:1810/262452 • DOI: 10.17863/CAM.7715

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Abstract

Mutation BRCA1 Protein Genes BRCA1 brca2 gene single nucleotide polymorphism Receptors Estrogen Breast Diagnosis Breast Cancer ovarian cancer cancer risk estrogen receptor negative Genome-Wide Association Study brca2 mutation