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Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

D Klenerman, M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman

OAI: oai:www.repository.cam.ac.uk:1810/265138 • DOI: 10.17863/CAM.11165

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Abstract

protein aggregation amyloid toxicity neurodegeneration aggregation inhibitors Antibody single-molecule fluorescence