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Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
David Gyori, Ee Lyn Lim, Francis M Grant, Dominik Spensberger, Rahul Roychoudhuri, Stephen J Shuttleworth, Klaus Okkenhaug, Len R Stephens, Phillip T Hawkins
OAI: oai:www.repository.cam.ac.uk:1810/278964 • DOI: 10.17863/CAM.26346
Abstract
cancer immunotherapy immunology MACROPHAGES oncology T cells Aminopyridines Animals Cell Line Tumor Class I Phosphatidylinositol 3-Kinases Diphtheria Toxin Disease Models Animal Drug Resistance Neoplasm Female Forkhead Transcription Factors Gene Knockout Techniques Humans Lymphocyte Depletion MACROPHAGES Male Mice Mice Transgenic Neoplasms Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Primary Cell Culture Purines Pyrroles Quinazolinones Receptors Granulocyte-Macrophage Colony-Stimulating Factor T-Lymphocytes Regulatory Tumor Microenvironment