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The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.
Peter St George-Hyslop, Julie Qiaojin Lin, Akinori Miyashita, Emma C Phillips, Seema Qamar, Suzanne J Randle, GuoZhen Wang
OAI: oai:www.repository.cam.ac.uk:1810/279263 • DOI: 10.17863/CAM.26643
Abstract
Amyotrophic Lateral Sclerosis arginine methylation Cation-pi interactions frontotemporal dementia phase separation RNA binding proteins Amyotrophic Lateral Sclerosis biophysics Cytoplasmic Granules DNA-Binding Proteins frontotemporal dementia Frontotemporal Lobar Degeneration Humans Mutation Neurodegenerative Diseases Protein Domains Protein Processing Post-Translational RNA-Binding Protein FUS RNA-Binding Proteins Temporal Lobe