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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.
Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Rafeah Alam, Valentina Carbonaro, Jonathan Clark, Srividya Sriskantharajah, Glyn Bradley, Alex G Richter, Edward Banham-Hall, Menna R Clatworthy, Sergey Nejentsev, J Nicole Hamblin, Edith M Hessel, Alison M Condliffe, Klaus Okkenhaug
OAI: oai:www.repository.cam.ac.uk:1810/283518 • DOI: 10.17863/CAM.30881
Abstract
Animals Antigens CD19 B-Lymphocytes Class I Phosphatidylinositol 3-Kinases Enzyme Activation Female Gene Knock-In Techniques Genotype Humans Interleukin-10 Lung Male Mice Mice Inbred C57BL Neutrophils Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Pneumococcal Infections Signal Transduction Species Specificity Streptococcus pneumoniae