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Histidine metabolism boosts cancer therapy.
Christian Frezza
OAI: oai:www.repository.cam.ac.uk:1810/284486
•
DOI: 10.17863/CAM.31862
Published by:
Abstract
Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice.
Cancer
medical research
metabolism
Histidine
Humans
Methotrexate
Mutation
Neoplasms
Research