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Histidine metabolism boosts cancer therapy.

OAI: oai:www.repository.cam.ac.uk:1810/284486 DOI: 10.17863/CAM.31862
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Abstract

Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice.