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Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates.
Remkes A Scheele, Laurens H Lindenburg, Maya Petek, Markus Schober, Kevin N Dalby, Florian Hollfelder
OAI: oai:www.repository.cam.ac.uk:1810/335043 • DOI: 10.17863/CAM.82482
Abstract
Catalysis Epistasis Genetic Humans MAP Kinase Kinase 1 MAP Kinase Signaling System Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinases Molecular Docking Simulation Phosphates Phosphorylation Protein Domains Protein Kinases Protein-Tyrosine Kinases Signal Transduction Substrate Specificity