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Neuroprotection of retinal ganglion cells by a novel gene therapy construct that achieves sustained enhancement of brain-derived neurotrophic factor/tropomyosin-related kinase receptor-B signaling.
Andrew Osborne, Tasneem Z Khatib, Lalana Songra, Amanda C Barber, Katie Hall, George YX Kong, Peter S Widdowson, Keith R Martin
OAI: oai:www.repository.cam.ac.uk:1810/285329 • DOI: 10.17863/CAM.27349
Abstract
Animals Axons Brain-Derived Neurotrophic Factor Dependovirus Disease Models Animal Down-Regulation Genetic Therapy Glaucoma HEK293 Cells Humans Intraocular Pressure Male Membrane Glycoproteins Mice Mice Inbred C57BL Neuroprotection Optic Nerve Injuries Rats Rats Sprague-Dawley Receptor trkB Retina Retinal Ganglion Cells Signal Transduction