Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.

Emma N Cahill, Amy L Milton

OAI: oai:www.repository.cam.ac.uk:1810/288139 • DOI: 10.17863/CAM.35455

Extinction within the reconsolidation window, or 'retrieval-extinction', has received much research interest as a possible technique for targeting the reconsolidation of maladaptive memories with a behavioural intervention. However, it remains to be determined whether the retrieval-extinction effect-a long-term reduction in fear behaviour, which appears resistant to spontaneous recovery, renewal and reinstatement-depends specifically on destabilisation of the original memory (the 'reconsolidation-update' account) or represents facilitation of an extinction memory (the 'extinction-facilitation' account). We propose that comparing the neurotransmitter systems, receptors and intracellular signalling pathways recruited by reconsolidation, extinction and retrieval-extinction will provide a way of distinguishing between these accounts.

Behaviour Extinction Memory reconsolidation Retrieval-Extinction Animals Conditioning Psychological Extinction Psychological Fear Humans Memory Receptors Dopamine Receptors N-Methyl-D-Aspartate