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Krebs Cycle Reimagined
OAI: oai:www.repository.cam.ac.uk:1810/287097 • DOI: 10.17863/CAM.34407
Abstract
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.