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p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.
Ivano Amelio, Mara Mancini, Varvara Petrova, Rob A Cairns, Polina Vikhreva, Sara Nicolai, Alberto Marini, Alexey A Antonov, John Le Quesne, Juvenal D Baena Acevedo, Kate Dudek, Gabriella Sozzi, Ugo Pastorino, Richard A Knight, Tak W Mak, Gerry Melino
OAI: oai:www.repository.cam.ac.uk:1810/286320 • DOI: 10.17863/CAM.33630
Abstract
HIF SWI/SNF Chromatin architecture microenvironment p53 Animals Carcinoma Non-Small-Cell Lung Cell Hypoxia Cell Line Tumor Extracellular Matrix Genes p53 Heterografts Humans Hypoxia-Inducible Factor 1 Lung Neoplasms Mice Mice Inbred BALB C Mice Nude Mutation Transcriptional Activation Tumor Microenvironment Tumor Suppressor Protein p53