Multimodality characteristics of multifocal choroid plexus carcinoma with bilateral calvarial defects in a dog.

Jonathan R Hughes, Frances E Taylor-Brown, Oliver Greville-Heygate, Fernando Constantino-Casas, David L Williams, Marie-Aude Genain

OAI: oai:www.repository.cam.ac.uk:1810/292260 • DOI: 10.17863/CAM.39409

An 8-year-old male intact miniature poodle presented for blindness, obtundation, tetraparesis, and vestibular signs. Magnetic resonance imaging, radiography, and ultrasound revealed a left piriform lobe lesion, right cerebellar and left brainstem lesions, and hydrocephalus and bilateral calvarial defects. Histopathology confirmed a choroid plexus carcinoma with meningeal and intraventricular metastases. The calvarial defect did not show evidence of necrosis, osteoclastic resorption, inflammation or neoplastic infiltration, reflecting a quiescent calvarial atrophy or dysplasia. These novel findings supported inclusion of bone atrophy secondary to chronic increased intracranial pressure as a differential diagnosis for large calvarial defects in dogs with choroid plexus carcinoma.

brain neoplasia calvarium skull defect Animals Carcinoma Choroid Plexus Neoplasms Dog Diseases Dogs Magnetic Resonance Imaging Male Multimodal Imaging Skull Ultrasonography