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Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells.
Lisa J Alcock, Bruno L Oliveira, Michael J Deery, Tara L Pukala, Michael V Perkins, Gonçalo JL Bernardes, Justin M Chalker
OAI: oai:www.repository.cam.ac.uk:1810/292620 • DOI: 10.17863/CAM.39781
Abstract
Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is highly selective and revealed a different reactivity profile than the traditional dimedone reagent. The norbornene probe also revealed a superior chemoselectivity when compared to a commonly used dimedone probe. Together, these results advance the study of cysteine oxidation in biological systems.