SpatialDE

Valentine Svensson, Sarah A Teichmann, Oliver Stegle

OAI: oai:www.repository.cam.ac.uk:1810/307981 • DOI: 10.17863/CAM.55077

Technological advances have made it possible to measure spatially resolved gene expression at high throughput. However, methods to analyze these data are not established. Here we describe SpatialDE, a statistical test to identify genes with spatial patterns of expression variation from multiplexed imaging or spatial RNA-sequencing data. SpatialDE also implements 'automatic expression histology', a spatial gene-clustering approach that enables expression-based tissue histology.

Breast Neoplasms Female Gene Expression Regulation Neoplastic Humans Models Biological Protein Transport Single-Cell Analysis