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Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation.

Daniel Ortmann, Stephanie Brown, Anne Czechanski, Selcan Aydin, Daniele Muraro, Yuanhua Huang, Rute A Tomaz, Anna Osnato, Giovanni Canu, Brandon T Wesley, Daniel A Skelly, Oliver Stegle, Ted Choi, Gary A Churchill, Christopher L Baker, Peter J Rugg-Gunn, Steven C Munger, Laura G Reinholdt, Ludovic Vallier

OAI: oai:www.repository.cam.ac.uk:1810/308520 • DOI: 10.17863/CAM.55606

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Abstract

DIFFERENTIATION eQTL Genetics Ground state Mouse embryonic stem cells Naïve Pluripotent Stem Cells signaling variability Animals Biological Variation Population Cell Differentiation genetic variation Induced Pluripotent Stem Cells Mice Pluripotent Stem Cells Reproducibility of Results