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SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.
Guillaume M Hautbergue, Lydia M Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S Bauer, Jennifer E Dodd, Monika A Myszczynska, Sarah M Alam, Pierre Garneret, Jayanth S Chandran, Evangelia Karyka, Matthew J Stopford, Emma F Smith, Janine Kirby, Kathrin Meyer, Brian K Kaspar, Adrian M Isaacs, Sherif F El-Khamisy, Kurt J De Vos, Ke Ning, Mimoun Azzouz, Alexander J Whitworth, Pamela J Shaw
OAI: oai:www.repository.cam.ac.uk:1810/291110 • DOI: 10.17863/CAM.38291
Abstract
Adult Aged Amyotrophic Lateral Sclerosis Animals Astrocytes C9orf72 Protein Cell Line Coculture Techniques Disease Models Animal Drosophila Female frontotemporal dementia Humans Male Mice Middle Aged Nuclear Proteins Nucleocytoplasmic Transport Proteins RNA-Binding Proteins Rats Serine-Arginine Splicing Factors Transcription Factors