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Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling.
Jennifer L Harman, Lina Dobnikar, Joel Chappell, Benjamin G Stokell, Amanda Dalby, Kirsty Foote, Alison Finigan, Paula Freire-Pritchett, Annabel L Taylor, Matthew D Worssam, Ralitsa R Madsen, Elena Loche, Anna Uryga, Martin R Bennett, Helle F Jørgensen
OAI: oai:www.repository.cam.ac.uk:1810/295535 • DOI: 10.17863/CAM.42590
Abstract
arteries Chromatin Immunoprecipitation Cytokines epigenetics histone Inflammation Animals Coronary Artery Disease Demethylation Epigenesis Genetic Gene Expression Histone-Lysine N-Methyltransferase Histones Humans Inflammation Interleukin-6 Male Matrix Metalloproteinases Mice Inbred C57BL Mitogen-Activated Protein Kinases Muscle Smooth Vascular Myocytes Smooth Muscle NF-kappa B Transcription Factor AP-1