Gonadotrophin-independent Precocious Puberty Secondary to an Estrogen Secreting Adrenal Tumor.

Xanthippi Tseretopoulou, Matthew J Murray, Jackie Buck, C Elizabeth Hook, Claire Jackson, Vasilis Kosmoliaptsis, Jacqueline Hughes, Samantha Gorman, Rachel M Williams

OAI: oai:www.repository.cam.ac.uk:1810/321231 • DOI: 10.17863/CAM.68353

BACKGROUND: Adrenal masses are rare in children and most commonly present with clinical features of virilization in the absence of activation of the pituitary axis-gonadotrophin-independent precocious puberty. OBSERVATIONS: We report an unusual case of a 7-year-old girl who presented with clinical signs suggestive of exposure to both androgens and estrogens. Imaging revealed a left-sided adrenal mass with no evidence of metastasis. She underwent successful laparoscopic unilateral adrenalectomy. Histology confirmed an adrenal adenoma. CONCLUSION: We conclude that adrenocortical tumors should be considered in children presenting with gonadotrophin-independent precocious puberty and raised estrogens.

Adrenal Gland Neoplasms Adrenocortical Adenoma Child Estrogens Female Humans Puberty Precocious