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Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Amanda K Chaplin, Steven W Hardwick, Antonia Kefala Stavridi, Christopher J Buehl, Noah J Goff, Virginie Ropars, Shikang Liang, Taiana Maia De Oliveira, Dimitri Y Chirgadze, Katheryn Meek, Jean-Baptiste Charbonnier, Tom L Blundell
OAI: oai:www.repository.cam.ac.uk:1810/325080 • DOI: 10.17863/CAM.72535
Abstract
DNA Repair DNA-PK NHEJ cryo-EM long-range synaptic complexes Non-homologous end joining Apoptosis Cryoelectron Microscopy DNA Breaks Double-Stranded DNA Damage DNA End-Joining Repair DNA Ligase ATP DNA Repair DNA Repair Enzymes DNA-Activated Protein Kinase DNA-Binding Proteins Humans Ku Autoantigen Multiprotein Complexes Phosphorylation