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Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program.
Ranna El-Khairi, Evelyn Olszanowski, Daniele Muraro, Pedro Madrigal, Katarzyna Tilgner, Mariya Chhatriwala, Sapna Vyas, Crystal Y Chia, Ludovic Vallier, Santiago A Rodríguez-Seguí
OAI: oai:www.repository.cam.ac.uk:1810/327649 • DOI: 10.17863/CAM.75104
Abstract
HNF1B MODY5 Diabetes DIFFERENTIATION Human induced pluripotent stem cells iPSC in vitro monogenic Pancreas β cell Biomarkers CRISPR-Cas Systems Cell Differentiation Cell Lineage Diabetes mellitus Disease Susceptibility Fluorescent Antibody Technique Gene Editing Gene Expression Profiling Gene Expression Regulation Developmental Haploinsufficiency Hepatocyte Nuclear Factor 1-beta Humans Immunophenotyping Induced Pluripotent Stem Cells Insulin-Secreting Cells Models Biological Organogenesis Pancreas Signal Transduction