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The WIRE study a phase II, multi-arm, multi-centre, non-randomised window-of-opportunity clinical trial platform using a Bayesian adaptive design for proof-of-mechanism of novel treatment strategies in operable renal cell cancer – a study protocol

Stephan Ursprung, Helen Mossop, Ferdia A. Gallagher, Evis Sala, Richard Skells, Jamal A. N. Sipple, Thomas J. Mitchell, Anita Chhabra, Kate Fife, Athena Matakidou, Gemma Young, Amanda Walker, Martin G. Thomas, Mireia Crispin Ortuzar, Mark Sullivan, Andrew Protheroe, Grenville Oades, Balaji Venugopal, Anne Y. Warren, John Stone, Tim Eisen, James Wason, Sarah J. Welsh, Grant D. Stewart

OAI: oai:www.repository.cam.ac.uk:1810/330889 • DOI: 10.17863/CAM.78332

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Abstract

Study Protocol Clinical trial protocol [MeSH] Clear cell renal cell carcinoma [MeSH] Phase II clinical trial [MeSH] Bayesian adaptive trial Olaparib [MeSH] Cediranib [MeSH] Durvalumab [MeSH] Window-of-opportunity Neoadjuvant therapy [MeSH]