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Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation.

Carolina T Orozco, Matthew J Edgeworth, Paul WA Devine, Alistair R Hines, Owen Cornwell, Christopher Thompson, Xiangyang Wang, Jonathan J Phillips, Peter Ravn, Sophie E Jackson, Nicholas J Bond

OAI: oai:www.repository.cam.ac.uk:1810/330557 • DOI: 10.17863/CAM.78001

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Abstract

Antibodies Monoclonal Antibody Specificity Antineoplastic Agents Binding Sites Drug Design Immunoconjugates Models Molecular Protein Conformation Sulfhydryl Compounds