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Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase.

Umberto Maria Battisti, Chunxia Gao, Oscar Nilsson, Fady Akladios, Aleksei Lulla, Agnieszka Bogucka, Amalyn Nain-Perez, Liliana Håversen, Woonghee Kim, Jan Boren, Marko Hyvönen, Mathias Uhlen, Adil Mardinoglu, Morten Grøtli

OAI: oai:www.repository.cam.ac.uk:1810/343070 • DOI: 10.17863/CAM.90481

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Abstract

PKL covalent activators Enzymes ligand design structure-activity relationships Humans Pyruvate Kinase Lysine Tandem Mass Spectrometry Liver Catalytic Domain Allosteric Regulation