Cover Image for System.Linq.Enumerable+EnumerablePartition`1[System.Char]

Thiazole formation through a modified Gewald reaction.

Carl J Mallia, Lukas Englert, Gary C Walter, Ian R Baxendale

OAI: oai:www.repository.cam.ac.uk:1810/324028 • DOI: 10.17863/CAM.71488

Published by:

Abstract

The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group.

1 4-dithiane-2 5-diol Gewald reaction design of experiment (DOE) thiazole thiophene