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The kinetics of bulk hydration of the disaccharides α-lactose and trehalose by <i>in situ</i> neutron powder diffraction
Valeska P. Ting, Marc Schmidtmann, Paul F. Henry, Sandie E. Dann, Jenna L. Crisp, Chick C. Wilson, Mark T. Weller
OAI: oai:purehost.bath.ac.uk:publications/c259caec-922b-424a-a590-6cfaebcc6e5e • DOI: https://doi.org/10.1039/c0md00093k
Abstract
The hydrations of the excipients stable α-lactose (Lαs), with two particle sizes, and trehalose have been studied by neutron powder diffraction; analysis of the Avrami plots, derived from the bulk polycrystalline phase compositions, allows elucidation of the kinetics and mechanisms involved in these hydration processes.