Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering

Xujun Wu, Matthew D Jones, Matthew G Davidson, Julian B Chaudhuri, Marianne J Ellis

OAI: oai:purehost.bath.ac.uk:publications/22da1dc9-2d4d-4ac7-9c8e-0829e84754c5 • DOI: https://doi.org/10.1007/s10529-010-0438-y

One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.