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NMR diffusion-ordered spectroscopy can explain differences in skin penetration enhancement between microemulsion formulations
OAI: oai:purehost.bath.ac.uk:publications/824a45ad-8d21-4c7c-8657-7beb1e41fb16 • DOI: https://doi.org/10.1016/j.nano.2014.06.006
Abstract
Changing the formulation variables of microemulsion systems has a significant influence on the resulting transdermal enhancement effect. NMR diffusion-ordered spectroscopy (DOSY) can offer an extremely valuable tool to interpret the differences in the obtained fluxes based on variations in self-diffusions between the drug and its locus domain.