Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii)

M. Li, H. Ge, R.L. Arrowsmith, V. Mirabello, S.W. Botchway, W. Zhu, S.I. Pascu, T.D. James

OAI: oai:purehost.bath.ac.uk:publications/1870784f-5718-4013-824f-1edc08e686b0 • DOI: https://doi.org/10.1039/c4cc03453h

Copper ions are essential for many biological processes. However, high concentrations of copper can be detrimental to the cell or organism. A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was investigated as a Cu² selective fluorescent sensor in living cells. This derivative is one of the rare examples of reversible fluorescent chemosensors for Cu²  which uses a boronic acid group for a binding site. Moreover, the adduct BNP-Cu² displays a fluorescence enhancement with fructose. The uptake of this novel compound in HeLa cancer cells was imaged using confocal fluorescence microscopy techniques including two-photon fluorescence lifetime imaging microscopy.

/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being