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Synthetic tools for studying the chemical biology of InsP<sub>8</sub>

Andrew M. Riley, Huanchen Wang, Stephen B. Shears, Barry V L Potter

OAI: oai:purehost.bath.ac.uk:publications/4e995215-86ab-451a-a0c7-8a08adaebb4c • DOI: https://doi.org/10.1039/c5cc05017k

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Abstract

To synthesise stabilised mimics of InsP₈, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP₈ metabolism.