Cysteine-cystine redox cycling in a gold-gold dual-plate generator-collector microtrench sensor

Jules L Hammond, Andrew Gross, Pedro Estrela, Jesus Iniesta, Stephen J. Green, C Peter Winlove, Peter G. Winyard, Nigel Benjamin, Frank Marken

OAI: oai:purehost.bath.ac.uk:publications/5021a0ea-b91c-49e8-9e0c-58e79371df9d • DOI: https://doi.org/10.1021/ac501321e

Thiols and disulfides are ubiquitous and important analytical targets. However, their redox properties, in particular on gold sensor electrodes, are complex and obscured by strong adsorption. Here, a gold–gold dual-plate microtrench dual-electrode sensor with feedback signal amplification is demonstrated to give well-defined (but kinetically limited) steady-state voltammetric current responses for the cysteine-cystine redox cycle in nondegassed aqueous buffer media at pH 7 down to micromolar concentration levels.