Comparison of effects of Enalapril, Ramipril and Amlodipine on blood sugar levels in ill-controlled type 2 Diabetes mellitus patients

Balani ND, Bachewar NP, Ahire NS, Choudhari S and Gaikwad A

Introduction: Insulin resistance, dyslipidemia and hypertension may co-exist in 15-25 % of individuals in industrialized countries. Vasodilator amodipine, ramipril and enalapril being commonly used drugs, were selected to see their beneficial effect in type 2 diabetics with fasting blood sugar >150 mg%.Materials and methods: This was a prospective, open labeled study in which 45 patients of type 2 diabetes mellitus with fasting blood glucose more than 150 mg% were allocated to 3 groups (n=15) each of Amlodipine 2.5mg/day, enalapril 2.5mg/day and ramipril 2.5mg/day for a follow up observation period of 8 weeks and blood glucose was estimated at the baseline and every 15 days.Results: In all the three study groups, statistically significant (p<0.05) reduction in the fasting blood glucose was found when compared to the ‘baseline’ and also ‘within group’ analysis. Add on therapy with vasodilator in such patients of diabetes mellitus was found to be associated with improved glycemic control at the end of 8 weeks.Conclusion: By addition of vasodilators to their current anti-diabetic treatment we tried to probe better control of type 2 Diabetes Mellitus patients with improved insulin responsiveness and decreased dose requirement of antidiabetic drugs.