Increased cardiac output and left ventricular contractility in pigs paced with vs. without restored respiratory sinus arrhythmia - proof of principle of a newly developed pacing device

Martin Riesenhuber, Andreas Spannbauer, E Hasimbegovic, K Muller-Zlabinger, D Lukovic, K Hamzaraj, E Han, R Hemetsberger, Soren Asmul, Martin Leonhardt, Chandrabhan Kushwah, Alain Nogaret, C Hengstenberg, Mariann Gyongyosi

OAI: oai:purehost.bath.ac.uk:openaire_cris_publications/390a9cf0-32ea-4429-9839-d764a8c48740 • DOI: https://doi.org/10.1093/eurheartj/ehad655.3169

Heart rate variability (HRV) correlates with the severity and mortality of heart failure. Respiratory sinus arrhythmia (RSA) is defined by the dynamic increase and decrease in heart rate between breaths. Restoration of RSA might be beneficial in patients with heart failure and/or patients in need of permanent pacing. The aim of this translational, proof-of-principle study was to investigate the effect of pacing with or without RSA using a newly designed pacing device on the left ventricular contractility and cardiac output.