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Results: 28
Neuroinflammation predicts disease progression in progressive supranuclear palsy
Maura Malpetti, Luca Passamonti, Peter Simon Jones, Duncan Street, Timothy Rittman, Timothy D Fryer, Young T Hong, Patricia Vàsquez Rodriguez, William Richard Bevan-Jones, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe
Mar 22, 2021
Introduction: In addition to tau pathology and neuronal loss, neuroinflammation occurs in progressive supranuclear palsy (PSP). However, the prognostic value of the in vivo imaging markers for these processes in PSP remains...
Published by: BMJ Publishing Group
Body mass index, prudent diet score and social class across three generations
Sarah Carter, Camille Parsons, Kate Ward, Michael Clynes, Elaine M Dennison, Cyrus Cooper
Jan 11, 2021
Background: Studies describing body mass index (BMI) and prudent diet score have reported that they are associated between parents and children. The Hertfordshire Intergenerational Study, which contains BMI, diet and social...
Published by: BMJ Publishing Group
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes
David Unwin, Ali Ahsan Khalid, Jen Unwin, Dominic Crocombe, Christine Delon, Kathy Martyn, Rajina Golubic, Sumantra Ray
Oct 27, 2020
Background: In a single general practice (GP) surgery in England, there was an eightfold increase in the prevalence of type 2 diabetes (T2D) in three decades with 57 cases and 472 cases recorded in 1987 and 2018, respectively....
Original Research 1506 Diabetes mellitus dietary patterns weight management blood pressure lowering lipid lowering
Published by: BMJ Publishing Group
Efficacy of spoken word comprehension therapy in patients with chronic aphasia
Victoria Fleming, Sonia Brownsett, Anna Krason, Maria A Maegli, Henry Coley-Fisher, Yean-Hoon Ong, Davide Nardo, Rupert Leach, David Howard, Holly Robson, Elizabeth Warburton, John Ashburner, Cathy J Price, Jenny T Crinion, Alexander P Leff
Nov 09, 2020
Objective: The efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, ‘Listen-In’, and examined the relation between brain...
Published by: BMJ Publishing Group
In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease
Audrey Low, Elijah Mak, Maura Malpetti, Luca Passamonti, Nicolas Nicastro, James D Stefaniak, George Savulich, Leonidas Chouliaras, Li Su, James B Rowe, Hugh S Markus, John T O'Brien
Sep 15, 2020
Introduction: Associations between cerebral small vessel disease (SVD) and inflammation have been largely examined using peripheral blood markers of inflammation, with few studies measuring inflammation within the brain. We...
Published by: BMJ Publishing Group
Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease
Jonathan Tay, Robin G Morris, Anil M Tuladhar, Masud Husain, Frank-Erik de Leeuw, Hugh S Markus
Jul 14, 2020
Objective: To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods: Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging in...
Published by: BMJ Publishing Group
Association between plant-based diets and blood pressure in the INTERMAP study
Ghadeer Aljuraiban, Queenie Chan, Rachel Gibson, Jeremiah Stamler, Martha L Daviglus, Alan R Dyer, Katsuyuki Miura, Yangfeng Wu, Hirotsugu Ueshima, Liancheng Zhao, Linda Van Horn, Paul Elliott, Linda M Oude Griep
Jul 10, 2020
Background: Plant-based diets are associated with a lower risk of cardiovascular diseases; however, little is known how the healthiness of the diet may be associated with blood pressure (BP). We aimed to modify three plant...
Published by: BMJ Publishing Group
Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis
Nick Cunniffe, Khue Anh Vuong, Debbie Ainslie, David Baker, Judy Beveridge, Sorrel Bickley, Patrick Camilleri, Matthew Craner, Denise Fitzgerald, Alerie G de la Fuente, Gavin Giovannoni, Emma Gray, Lorraine Hazlehurst, Raj Kapoor, Ranjit Kaur, David Kozlowski, Brooke Lumicisi, Don Mahad, Björn Neumann, Alan Palmer, Luca Peruzzotti-Jametti, Stefano Pluchino, Jennifer Robertson, Alan Rothaul, Lyndsey Shellard, Kenneth J Smith, Alastair Wilkins, Anna Williams, Alasdair Coles
Nov 16, 2020
Objective: To establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS). Methods: We...
Published by: BMJ Publishing Group
Time for nutrition in medical education
Elaine Macaninch, Luke Buckner, Preya Amin, Iain Broadley, Dominic Crocombe, Duleni Herath, Ally Jaffee, Harrison Carter, Rajina Golubric, Minha Rajput-Ray, Kathy Martyn, Sumantra Ray
Apr 30, 2020
Aim: To synthesise a selection of UK medical students’ and doctors’ views surrounding nutrition in medical education and practice. Methods: Information was gathered from surveys of medical students and doctors identified between...
Published by: BMJ Publishing Group
NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia
Bernard P H Cho, Stefania Nannoni, Eric L Harshfield, Daniel Tozer, Stefan Gräf, Steven Bell, Hugh S Markus
Mar 17, 2021
Background: Cysteine-altering NOTCH3 variants identical to those causing the rare monogenic form of stroke, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), have been reported...
Published by: BMJ Publishing Group
Are better existing WASH practices in urban slums associated with a lower long-term risk of severe cholera? A prospective cohort study with 4 years of follow-up in Mirpur, Bangladesh
Sophie Kang, Fahima Chowdhury, Juyeon Park, Tasnuva Ahmed, Birkneh Tilahun Tadesse, Md. Taufiqul Islam, Deok Ryun Kim, Justin Im, Asma Binte Aziz, Masuma Hoque, Gideok Pak, Farhana Khanam, Faisal Ahmmed, Xinxue Liu, K Zaman, Ashraful Islam Khan, Jerome H Kim, Florian Marks, Firdausi Qadri, John D Clemens
Oct 17, 2022
Published by: BMJ Publishing Group
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes
David Unwin, Ali Ahsan Khalid, Jen Unwin, Dominic Crocombe, Christine Delon, Kathy Martyn, Rajna Golubic, Sumantra Ray
Nov 09, 2020
Background: In a single general practice (GP) surgery in England, there was an eightfold increase in the prevalence of type 2 diabetes (T2D) in three decades with 57 cases and 472 cases recorded in 1987 and 2018, respectively....
Original Research 1506 Diabetes mellitus dietary patterns weight management blood pressure lowering lipid lowering
Published by: BMJ Publishing Group
Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington’s disease (Enroll-HD)
Objectives: Alterations in dopamine neurotransmission underlie some of the clinical features of Huntington’s disease (HD) and as such are a target for therapeutic intervention, especially for the treatment of chorea and some...
Published by: BMJ Publishing Group
Regional hyperperfusion in cognitively normal APOE ε4 allele carriers in mid-life
Elizabeth Frances McKiernan, Elijah Mak, Maria-Eleni Dounavi, Katie Wells, Craig Ritchie, Guy Williams, Li Su, John O'Brien
Jun 26, 2020
Background: Regional cerebral hypoperfusion is characteristic of Alzheimer’s disease (AD). Previous studies report conflicting findings in cognitively normal individuals at high risk of AD. Understanding early preclinical...
Published by: BMJ Publishing Group
Cost-effectiveness of vitamin D 3 supplementation in older adults with vitamin D deficiency in Ireland
Laurence Francis Lacey, David J Armstrong, Emily Royle, Pamela Magee, L Kirsty Pourshahidi, Sumantra Ray, J J Strain, Emeir McSorley
Jun 07, 2022
Background: This study investigated the cost-effectiveness of vitamin D3 supplementation in older adults in Ireland, with year-round vitamin D deficiency (serum 25-hydroxyvitamin D concentration <30 nmol/L) (13% of Irish...
Published by: BMJ Publishing Group
Review: Multiple sclerosis in the digital age
Alastair Compston
Jul 27, 2020
Published by: BMJ Publishing Group
MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementia
Ana L Manera, Mahsa Dadar, John Cornelis van Swieten, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce Jr, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James Benedict Rowe, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Christopher R Butler, Alex Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Jonathan Daniel Rohrer, Simon Ducharme, D Louis Collins, FTLDNI investigators, Howard Rosen, Bradford C. Dickerson, Kimoko Domoto-Reilly, David Knopman, Bradley F. Boeve, Adam L. Boxer, John Kornak, Bruce L. Miller, William W. Seeley, Maria-Luisa Gorno-Tempini, Scott McGinnis, Maria Luisa Mandelli, GENFI Consortium, Sónia Afonso, Maria Rosario Almeida, Sarah Anderl-Straub, Christin Andersson, Anna Antonell, Silvana Archetti, Andrea Arighi, Mircea Balasa, Myriam Barandiaran, Nuria Bargalló, Robart Bartha, Benjamin Bender, Alberto Benussi, Luisa Benussi, Valentina Bessi, Giuliano Binetti, Sandra Black, Martina Bocchetta, Sergi Borrego-Ecija, Jose Bras, Rose Bruffaerts, Paola Caroppo, David Cash, Miguel Castelo-Branco, Rhian Convery, Thomas Cope, Maura Cosseddu, María de Arriba, Giuseppe Di Fede, Zigor Díaz, Diana Duro, Chiara Fenoglio, Camilla Ferrari, Carlos Ferreira, Catarina B. Ferreira, Toby Flanagan, Nick Fox, Morris Freedman, Giorgio Fumagalli, Alazne Gabilondo, Roberto Gasparotti, Serge Gauthier, Stefano Gazzina, Giorgio Giaccone, Ana Gorostidi, Caroline Greaves, Rita Guerreiro, Carolin Heller, Tobias Hoegen, Begoña Indakoetxea, Vesna Jelic, Lize Jiskoot, Hans-Otto Karnath, Ron Keren, Maria João Leitão, Albert Lladó, Gemma Lombardi, Sandra Loosli, Carolina Maruta, Simon Mead, Lieke Meeter, Gabriel Miltenberger, Rick van Minkelen, Sara Mitchell, Katrina M Moore, Benedetta Nacmias, Mollie Neason, Jennifer Nicholas, Linn Öijerstedt, Jaume Olives, Sebastien Ourselin, Alessandro Padovani, Jessica Panman, Janne Papma, Georgia Peakman, Irene Piaceri, Michela Pievani, Yolande Pijnenburg, Cristina Polito, Enrico Premi, Sara Prioni, Catharina Prix, Rosa Rademakers, Veronica Redaelli, Tim Rittman, Ekaterina Rogaeva, Pedro Rosa-Neto, Giacomina Rossi, Martin Rossor, Beatriz Santiago, Elio Scarpini, Sonja Schönecker, Elisa Semler, Rachelle Shafei, Christen Shoesmith, Miguel Tábuas-Pereira, Mikel Tainta, Ricardo Taipa, David Tang-Wai, David L Thomas, Hakan Thonberg, Carolyn Timberlake, Pietro Tiraboschi, Emily Todd, Philip Vandamme, Mathieu Vandenbulcke, Michele Veldsman, Ana Verdelho, Jorge Villanua, Jason Warren, Carlo Wilke, Ione Woollacott, Elisabeth Wlasich, Henrik Zetterberg, Miren Zulaica
Mar 19, 2021
Introduction: Structural brain imaging is paramount for the diagnosis of behavioural variant of frontotemporal dementia (bvFTD), but it has low sensitivity leading to erroneous or late diagnosis. Methods: A total of 515 subjects...
Published by: BMJ Publishing Group
Early symptoms in symptomatic and preclinical genetic frontotemporal lobar degeneration
Tamara Paulo Tavares, Derek G V Mitchell, Kristy Kl Coleman, Brenda L Coleman, Christen L Shoesmith, Christopher R Butler, Isabel Santana, Adrian Danek, Alexander Gerhard, Alexandre de Mendonca, Barbara Borroni, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, Fabrizio Tagliavini, Fermin Moreno, Giovanni Frisoni, James Benedict Rowe, Johannes Levin, John Cornelis van Swieten, Markus Otto, Matthis Synofzik, Raquel Sanchez-Valle, Rik Vandenberghe, Robert Jr Laforce, Roberta Ghidoni, Sandro Sorbi, Simon Ducharme, Mario Masellis, Jonathan Rohrer, Elizabeth Finger
Aug 11, 2020
Published by: BMJ Publishing Group
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes
David Unwin, Ali Ahsan Khalid, Jen Unwin, Dominic Crocombe, Christine Delon, Kathy Martyn, Rajna Golubic, Sumantra Ray
Nov 11, 2020
Background: In a single general practice (GP) surgery in England, there was an eightfold increase in the prevalence of type 2 diabetes (T2D) in three decades with 57 cases and 472 cases recorded in 1987 and 2018, respectively....
Original Research 1506 Diabetes mellitus dietary patterns weight management blood pressure lowering lipid lowering
Published by: BMJ Publishing Group
Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia
Carolin Heller, Martha S Foiani, Katrina Moore, Rhian Convery, Martina Bocchetta, Mollie Neason, David M Cash, David Thomas, Caroline V Greaves, Ione OC Woollacott, Rachelle Shafei, John C van Swieten, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce Jr, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher R Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Giovanni Frisoni, Sandro Sorbi, Markus Otto, Amanda J Heslegrave, Henrik Zetterberg, Jonathan D Rohrer
Feb 07, 2020
Published by: BMJ Publishing Group
Trauma and depressive symptomatology in middle-aged persons at high risk of dementia
Karen Ritchie, Isabelle Carrière, Sarah Gregory, Tam Watermeyer, Samuel Danso, Li Su, Craig W Ritchie, John T O'Brien
Oct 23, 2020
Objective: Depression and trauma are associated with changes in brain regions implicated in Alzheimer’s disease. The present study examined associations between childhood trauma, depression, adult cognitive functioning and risk...
Published by: BMJ Publishing Group
Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson’s disease
Thomas B Stoker, Marta Camacho, Sophie Winder-Rhodes, Ganqiang Liu, Clemens R Scherzer, Thomas Foltynie, Jonathan Evans, David P Breen, Roger A Barker, Caroline H Williams-Gray
Apr 30, 2020
Published by: BMJ Publishing Group
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