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Results: 5
An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors
ESJ Smith, AS Stürzebecher, J Hu, S Frahm, J Santos-Torres, B Kampfrath, S Auer, GR Lewin, I Ibanez-Tallon
Aug 11, 2017
Animals Behavior Animal Blotting Southern Chromosomes Artificial Bacterial Conotoxins DNA Electrophysiology Female Immunohistochemistry In Situ Hybridization Ion Channel Gating Mice Mice Transgenic Neurons Afferent Nociceptors Oocytes Pain Patch-Clamp Techniques Reverse Transcriptase Polymerase Chain Reaction Skin Sodium Channel Blockers Sodium Channels Spinal Cord Xenopus laevis
Synaptic Inputs to the Mouse Dorsal Vagal Complex and Its Resident Preproglucagon Neurons.
Marie K Holt, Lisa E Pomeranz, Kevin T Beier, Frank Reimann, Fiona M Gribble, Linda Rinaman
Oct 16, 2019
GLP1 nodose ganglion Pseudorabies Rabies Stress viral tracing Animals Axons Female Hypothalamus Male Mice Mice Inbred C57BL Neural Pathways Neurons Neurons Afferent Posterior Horn Cells Proglucagon Reflex Monosynaptic Restraint Physical Solitary Nucleus Stress Psychological Synapses Thalamus Vagus Nerve
Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli.
Toni S Taylor, Parvesh Konda, Sarah S John, David C Bulmer, James RF Hockley, Ewan St John Smith
Jan 10, 2020
Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.
Van B Lu, Juraj Rievaj, Elisabeth A O'Flaherty, Christopher A Smith, Ramona Pais, Luke A Pattison, Gwen Tolhurst, Andrew B Leiter, David C Bulmer, Fiona M Gribble, Frank Reimann
Feb 12, 2019
Adenosine Triphosphate Afferent Pathways Animals Cell Line Eating Enterocytes Enteroendocrine Cells Female Ganglion Cysts Glucagon-Like Peptide 1 Incretins Intestinal Mucosa Intestines Male Mice Mice Inbred C57BL Neurons Neurons Afferent nodose ganglion Peptide YY Receptors Purinergic P2X2 Receptors Purinergic P2X3 Vagus Nerve
Functional and anatomical deficits in visceral nociception with age
Vincent Cibert-Goton, Victor WS Kung, Cian McGuire, James RF Hockley, Michael M Tranter, Harween Dogra, Abi Belai, L Ashley Blackshaw, Gareth J Sanger, Charles H Knowles, Eduardo JA Araujo, Wendy J Winchester, David C Bulmer
Jan 16, 2020
The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral...