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Results: 7
Reassessment of weak parent-of-origin expression bias shows it rarely exists outside of known imprinted regions.
Carol A Edwards, William MD Watkinson, Stephanie B Telerman, Lisa C Hulsmann, Russell S Hamilton, Anne C Ferguson-Smith
Apr 12, 2023
Drug-induced loss of imprinting revealed using bioluminescent reporters of Cdkn1c.
Andrew Dimond, Mathew Van de Pette, Victoria Taylor-Bateman, Karen Brown, Alessandro Sardini, Chad Whilding, Amelie Feytout, Rab K Prinjha, Matthias Merkenschlager, Amanda G Fisher
Apr 06, 2023
Naturally-occurring serotype 3 Streptococcus pneumoniae strains that lack functional pneumolysin and autolysin have attenuated virulence but induce localized protective immune responses.
Ηαnnah E Wong, Panagiotis Tourlomousis, Gavin K Paterson, Steve Webster, Clare E Bryant
Apr 09, 2023
Streptococcus pneumoniae is an important cause of fatal pneumonia in humans. These bacteria express virulence factors, such as the toxins pneumolysin and autolysin, that drive host inflammatory responses. In this study we...
Animals Horses Mice Streptococcus pneumoniae N-Acetylmuramoyl-L-alanine Amidase Tumor Necrosis Factor-alpha Bacterial Proteins Streptolysins Virulence Immunity Serogroup
Published by: PLOS ONE
Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR.
Jake R Thomas, Anna Appios, Emily F Calderbank, Nagisa Yoshida, Xiaohui Zhao, Russell S Hamilton, Ashley Moffett, Andrew Sharkey, Elisa Laurenti, Courtney W Hanna, Naomi McGovern
Apr 17, 2023
The earliest macrophages are generated during embryonic development from erythro-myeloid progenitors (EMPs) via primitive haematopoiesis. Although this process is thought to be spatially restricted to the yolk sac in the mouse...
MACROPHAGES Placenta Animals Humans Mice HLA-DR Antigens Hematopoiesis Embryonic Development Pregnancy Female
Published by: Nature Communications
Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools.
Dorota Zawada, Jessica Kornherr, Anna B Meier, Gianluca Santamaria, Tatjana Dorn, Monika Nowak-Imialek, Daniel Ortmann, Fangfang Zhang, Mark Lachmann, Martina Dreßen, Mariaestela Ortiz, Victoria L Mascetti, Stephen C Harmer, Muriel Nobles, Andrew Tinker, Maria Teresa De Angelis, Roger A Pedersen, Phillip Grote, Karl-Ludwig Laugwitz, Alessandra Moretti, Alexander Goedel
Apr 17, 2023
Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor populations. Understanding the specification and differentiation of these distinct progenitor pools during human embryonic development is...
Myocardium Heart Myocytes Cardiac Pluripotent Stem Cells Animals Humans Mice Tretinoin Cell Differentiation
Published by: Nature Communications
A rare human variant that disrupts GPR10 signalling causes weight gain in mice.
Fleur Talbot, Claire H Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles S H Yeo, Philippe Froguel, David A Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon M Luckman, I Sadaf Farooqi
Apr 15, 2023
Animals Mice Transgenic Humans Mice obesity Weight Gain Receptors G-Protein-Coupled Signal Transduction Energy Metabolism
Published by: Nature Communications
Fumarate induces vesicular release of mtDNA to drive innate immunity.
Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge MN Wortel, Jordan L Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana SH Costa, Gonçalo C Pereira, Laura Tronci, Timothy Young, Efterpi Nikitopoulou, Ming Yang, Dóra Bihary, Federico Caicci, Shun Nagashima, Alyson Speed, Kalliopi Bokea, Zara Baig, Shamith Samarajiwa, Maxine Tran, Thomas Mitchell, Mark Johnson, Julien Prudent, Christian Frezza
Apr 08, 2023
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma1. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate2....