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Type-2 innate lymphoid cells (ILC2) are a prominent source of type II cytokines and are found constitutively at mucosal surfaces and in visceral adipose tissue. Despite their role in limiting obesity, how ILC2s respond to high...

Adipose Tissue White Animals Aorta Atherosclerosis Bone Marrow Transplantation Cytokines Diet High-Fat Female Interleukin-13 Interleukin-5 Lymphocytes Mice Knockout ApoE Mice Mutant Strains Plaque Atherosclerotic

Objective- Recent studies suggested the occurrence of phenotypic switching of vascular smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However, lineage-tracing studies are still lacking, and the...

Angiotensin II Autophagy clones Endoplasmic Reticulum Inflammation Mice Smooth muscle cells Adult Aged aortic dissection Angiotensin II Animals Aorta Aortic Aneurysm Autophagy Autophagy-Related Protein 5 Cell Lineage Cell Plasticity Cells Cultured Disease Models Animal Endoribonucleases Female Humans Male Mice 129 Strain Mice Inbred C57BL Mice Knockout ApoE Middle Aged Muscle Smooth Vascular Myocytes Smooth Muscle Phenotype Protein Serine-Threonine Kinases Signal Transduction

The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory responses in several cardiovascular diseases but its role in abdominal aortic aneurysm (AAA) remains unknown. Our objective was to explore the...

cell migration/adhesion Inflammation innate immunity Monocytes vascular biology Angiotensin II Animals Aortic Aneurysm Abdominal Cell Movement Gene Deletion Humans Interleukin-1beta Matrix Metalloproteinase 2 Mice Mice Knockout ApoE Monocytes Triggering Receptor Expressed on Myeloid Cells-1 Tumor Necrosis Factor-alpha

Endothelial cells (ECs) play an important role in the pathogenesis of cardiovascular disease, especially atherosclerosis (AS). The abnormal wall shear stress (WSS) which directly contacts with ECs is the key stimulating factor...

Atherosclerosis Bioinformatics Endothelial Cells SRGN Shear stress Animals Atherosclerosis Endothelium Vascular Human Umbilical Vein Endothelial Cells Humans Mechanotransduction Cellular Mice Mice Knockout ApoE Neovascularization Pathologic Proteoglycans Shear strength Stress Mechanical Vesicular Transport Proteins

N-methyl-2-pyrrolidone (NMP) is a versatile water-miscible polar aprotic solvent. It is used as a drug solubilizer and penetration enhancer in human and animal, yet its bioactivity properties remain elusive. Here, we report that...

Animals Anti-Inflammatory Agents Aorta Apoptosis Atherosclerosis Cell Adhesion Cell Line DNA Complementary Endothelial Cells Gene Expression Profiling Gene Library Human Umbilical Vein Endothelial Cells Humans Inflammation Kruppel-Like Transcription Factors Mice Mice Knockout ApoE Monocytes Pyrrolidinones RNA Small Interfering Solvents Tumor Necrosis Factor-alpha

OBJECTIVE: Vascular smooth muscle cell (VSMC) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. The forkhead protein FOXO3a...

Muscle Smooth Vascular Cells Cultured Extracellular Matrix Myocytes Smooth Muscle Animals Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Humans Rats Wistar Carotid Artery Injuries Disease Models Animal Fibrosis Necrosis Signal Transduction Apoptosis Mutation Male Atherosclerosis Matrix Metalloproteinase 13 Transcriptional Activation Vascular Remodeling Forkhead Box Protein O3 Mice Knockout ApoE

BACKGROUND: Atherosclerotic plaques demonstrate extensive accumulation of oxidative DNA damage, predominantly as 8-oxoguanine (8oxoG) lesions. 8oxoG is repaired by base excision repair enzymes; however, the mechanisms regulating...

DNA Damage DNA Glycosylases Atherosclerosis Oxidative Stress Vascular diseases Acetylation Animals Atherosclerosis Biomarkers Cells Cultured DNA Damage DNA Glycosylases DNA Repair Disease Models Animal Female Guanine Humans Male Mice Knockout ApoE Muscle Smooth Vascular Myocytes Smooth Muscle Oxidative Stress Plaque Atherosclerotic Protein Processing Post-Translational Rats Sirtuin 1 p300-CBP Transcription Factors

BACKGROUND AND AIMS: Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously been...

Akt signaling Atherosclerosis DNA damage repair NEIL3 Phenotypic transdifferentiation Vascular smooth muscle cells Animals Atherosclerosis Cell Proliferation Cells Cultured DNA Glycosylases Endodeoxyribonucleases Humans Mice Mice Inbred C57BL Mice Knockout ApoE Muscle Smooth Vascular Myocytes Smooth Muscle N-Glycosyl Hydrolases Phenotype Plaque Atherosclerotic