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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes
LA Lotta, RA Scott, SJ Sharp, S Burgess, J Luan, T Tillin, AF Schmidt, F Imamura, ID Stewart, JRB Perry, L Marney, A Koulman, ED Karoly, NG Forouhi, RJO Sjögren, E Näslund, JR Zierath, A Krook, DB Savage, JL Griffin, N Chaturvedi, AD Hingorani, K-T Khaw, I Barroso, MI McCarthy, S O'Rahilly, NJ Wareham, C Langenberg
Jan 18, 2017
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana SH Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R Zecchini, Sabrina H Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y Warren, Grant D Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Jan 22, 2023
Metabolic reprogramming is critical for tumor initiation and progression. However, the exact impact of specific metabolic changes on cancer progression is poorly understood. Here, we integrate multimodal analyses of primary and...
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.
Adil Mardinoglu, Silvia Gogg, Luca A Lotta, Alena Stančáková, Annika Nerstedt, Jan Boren, Matthias Blüher, Ele Ferrannini, Claudia Langenberg, Nicholas J Wareham, Markku Laakso, Ulf Smith
Mar 02, 2018
Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify if...
3-Hydroxyisobutyric acid (3-HIB) Branched-chain amino acids (BCAAs) Insulin Resistance Insulin Secretion T2D Adipose Tissue Amino Acids Branched-Chain Biological Transport Body Mass Index Diabetes mellitus Type 2 Endothelial Cells Fatty Acids Humans Hydroxybutyrates Incidence Metabolome Microvessels
Treatment with antioxidants ameliorates oxidative damage in a mouse model of propionic acidemia.
Ana Rivera-Barahona, Esmeralda Alonso-Barroso, Belén Pérez, Michael P Murphy, Eva Richard, Lourdes R Desviat
Jun 18, 2018
Oxidative stress contributes to the pathogenesis of propionic acidemia (PA), a life threatening disease caused by the deficiency of propionyl CoA-carboxylase, in the catabolic pathway of branched-chain amino acids, odd-number...
Structures of fungal and plant acetohydroxyacid synthases.
Thierry Lonhienne, Yu Shang Low, Mario D Garcia, Tristan Croll, Yan Gao, Quan Wang, Lou Brillault, Craig M Williams, James A Fraser, Ross P McGeary, Nicholas P West, Michael J Landsberg, Zihe Rao, Gerhard Schenk, Luke W Guddat
Jun 03, 2020
Acetohydroxyacid synthase (AHAS), also known as acetolactate synthase, is a flavin adenine dinucleotide-, thiamine diphosphate- and magnesium-dependent enzyme that catalyses the first step in the biosynthesis of branched-chain...
Acetolactate Synthase Adenosine Triphosphate Amino Acids Branched-Chain Arabidopsis Catalytic Domain Enzyme Activation evolution Molecular Feedback Physiological Models Molecular Multiprotein Complexes Mycobacterium tuberculosis Protein Binding Protein Conformation Protein Subunits Saccharomyces cerevisiae Valine