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Pluripotency Deconstructed.
Pluripotency denotes the flexible capacity of single cells to give rise to all somatic lineages and typically also the germline. Mouse ES cells and post-implantation epiblast-derived stem cells (EpiSC) are widely used...
SoxNeuro orchestrates central nervous system specification and differentiation in Drosophila and is only partially redundant with Dichaete.
BACKGROUND: Sox proteins encompass an evolutionarily conserved family of transcription factors with critical roles in animal development and stem cell biology. In common with vertebrates, the Drosophila group B proteins SoxNeuro...
Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos.
Rachel E Jennings, Andrew A Berry, David T Gerrard, Stephen J Wearne, James Strutt, Sarah Withey, Mariya Chhatriwala, Karen Piper Hanley, Ludovic Vallier, Nicoletta Bobola, Neil A Hanley
May 14, 2018
Large-scale discovery of novel genetic causes of developmental disorders.
Deciphering Developmental Disorders Study
Feb 01, 2021
Despite three decades of successful, predominantly phenotype-driven discovery of the genetic causes of monogenic disorders, up to half of children with severe developmental disorders of probable genetic origin remain without a...
Adolescent Animals Carrier Proteins Child Child Preschool Chromosomal Proteins Non-Histone Chromosome Aberrations DEAD-box RNA Helicases DNA-Binding Proteins Developmental Disabilities Dynamin I Exome Female Gene Expression Regulation Developmental Genes Dominant Genome Human Guanine Nucleotide Exchange Factors Homeodomain Proteins Humans Infant Infant Newborn Male Mutation Missense Nerve Tissue Proteins Nuclear Proteins Parents Phosphoproteins Polycomb Repressive Complex 1 Protein Phosphatase 2 Protein Serine-Threonine Kinases Rare Diseases Repressor Proteins Transcription Factors Transposases United Kingdom Zebrafish
From bud formation to flowering
Noémie Vimont, Mathieu Fouché, José Antonio Campoy, Meixuezi Tong, Mustapha Arkoun, Jean-Claude Yvin, Philip A Wigge, Elisabeth Dirlewanger, Sandra Cortijo, Bénédicte Wenden
Dec 11, 2020
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Parimal Samir, Sannula Kesavardhana, Deanna M Patmore, Sebastien Gingras, RK Subbarao Malireddi, Rajendra Karki, Clifford S Guy, Benoit Briard, David E Place, Anannya Bhattacharya, Bhesh Raj Sharma, Amanda Nourse, Sharon V King, Aaron Pitre, Amanda R Burton, Stephane Pelletier, Richard J Gilbertson, Thirumala-Devi Kanneganti
Oct 25, 2019
Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid.
Berna Sozen, Andy L Cox, Joachim De Jonghe, Min Bao, Florian Hollfelder, David M Glover, Magdalena Zernicka-Goetz
Dec 19, 2019
Mammalian blastocysts comprise three distinct cell lineages essential for development beyond implantation: the pluripotent epiblast, which generates the future embryo, and surrounding it the extra-embryonic primitive endoderm...
Blastoid development Embryo Endoderm Extended pluripotency in vitro preimplantation Stem Cells trophoblast Animals Blastocyst Cell Differentiation Cell Lineage Embryo Implantation Embryo Mammalian Embryonic Development Endoderm Gene Expression Regulation Developmental Mice Mouse embryonic stem cells
An in vitro model of early anteroposterior organization during human development.
Naomi Moris, Kerim Anlas, Susanne C van den Brink, Anna Alemany, Julia Schröder, Sabitri Ghimire, Tina Balayo, Alexander van Oudenaarden, Alfonso Martinez Arias
Jun 16, 2020
The body plan of the mammalian embryo is shaped through the process of gastrulation, an early developmental event that transforms an isotropic group of cells into an ensemble of tissues that is ordered with reference to three...
Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.
Hannah T Stuart, Giuliano G Stirparo, Tim Lohoff, Lawrence E Bates, Masaki Kinoshita, Chee Y Lim, Elsa J Sousa, Katsiaryna Maskalenka, Aliaksandra Radzisheuskaya, Andrew A Malcolm, Mariana RP Alves, Rebecca L Lloyd, Sonia Nestorowa, Peter Humphreys, William Mansfield, Wolf Reik, Paul Bertone, Jennifer Nichols, Berthold Göttgens, José CR Silva
May 29, 2019
cell identity transitions Pluripotency reprogramming signaling transcriptional networks Animals Blastocyst Inner Cell Mass Cell Differentiation Cell Line Cell Plasticity Cellular Reprogramming Female Gene Expression Regulation Developmental Gene Regulatory Networks Germ Layers Mice Mice Inbred C57BL Octamer Transcription Factor-3 Pluripotent Stem Cells Signal Transduction
Neuro-mesodermal progenitors (NMPs)
The mammalian embryo's caudal lateral epiblast (CLE) harbours bipotent progenitors, called neural mesodermal progenitors (NMPs), that contribute to the spinal cord and the paraxial mesoderm throughout axial elongation. Here, we...
neuromesodermal progenitors Single cells Transcription Animals Body Patterning Cell Differentiation Cell Lineage Embryo Mammalian Embryonic Stem Cells Female Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Green Fluorescent Proteins In Vitro Techniques Male Mesoderm Mice Neural Stem Cells Pluripotent Stem Cells Spinal Cord Stem Cells Support Vector Machine Transcriptome
Common and distinct transcriptional signatures of mammalian embryonic lethality.
John E Collins, Richard J White, Nicole Staudt, Ian M Sealy, Ian Packham, Neha Wali, Catherine Tudor, Cecilia Mazzeo, Angela Green, Emma Siragher, Edward Ryder, Jacqueline K White, Irene Papatheodoru, Amy Tang, Anja Füllgrabe, Konstantinos Billis, Stefan H Geyer, Wolfgang J Weninger, Antonella Galli, Myriam Hemberger, Derek L Stemple, Elizabeth Robertson, James C Smith, Timothy Mohun, David J Adams, Elisabeth M Busch-Nentwich
Aug 08, 2019
The Deciphering the Mechanisms of Developmental Disorders programme has analysed the morphological and molecular phenotypes of embryonic and perinatal lethal mouse mutant lines in order to investigate the causes of embryonic...
The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism.
David J Jörg, Elizabeth E Caygill, Anna E Hakes, Esteban G Contreras, Andrea H Brand, Benjamin D Simons
Feb 15, 2019
D. melanogaster developmental biology Optic Lobe physics of living systems proneural wave reaction-diffusion system sequential patterning Animals Cell Differentiation Drosophila Drosophila Proteins ErbB Receptors Gene Expression Regulation Developmental Neuroepithelial Cells Neurons Optic Lobe Nonmammalian Receptors Invertebrate Peptide Signal Transduction
PAGA
F Alexander Wolf, Fiona K Hamey, Mireya Plass, Jordi Solana, Joakim S Dahlin, Berthold Göttgens, Nikolaus Rajewsky, Lukas Simon, Fabian J Theis
Feb 18, 2019
Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during Drosophila wing morphogenesis.
Jinghua Gui, Yunxian Huang, Martin Montanari, Daniel Toddie-Moore, Kenji Kikushima, Stephanie Nix, Yukitaka Ishimoto, Osamu Shimmi
Mar 26, 2019
At the level of organ formation, tissue morphogenesis drives developmental processes in animals, often involving the rearrangement of two-dimensional (2D) structures into more complex three-dimensional (3D) tissues. These...
bone morphogenetic protein Drosophila Epithelial morphogenesis live-imaging three-dimensional architecture Animals Bone Morphogenetic Proteins Cell Differentiation Cell Proliferation Drosophila Proteins Drosophila melanogaster Epithelium Gene Expression Regulation Developmental Gene Knockdown Techniques Morphogenesis Signal Transduction Wings Animal
Identifying targets of the Sox domain protein Dichaete in the Drosophila CNS via targeted expression of dominant negative proteins.
Advancing haematopoietic stem and progenitor cell biology through single-cell profiling.
The gene cortex controls mimicry and crypsis in butterflies and moths.
Nicola J Nadeau, Carolina Pardo-Diaz, Annabel Whibley, Megan A Supple, Suzanne V Saenko, Richard WR Wallbank, Grace C Wu, Luana Maroja, Laura Ferguson, Joseph J Hanly, Heather Hines, Camilo Salazar, Richard M Merrill, Andrea J Dowling, Richard H ffrench-Constant, Violaine Llaurens, Mathieu Joron, W Owen McMillan, Chris D Jiggins
Mar 18, 2016
Drosophila astrocytes cover specific territories of the CNS neuropil and are instructed to differentiate by Prospero, a key effector of Notch.
Emilie Peco, Sejal Davla, Darius Camp, Stephanie M Stacey, Matthias Landgraf, Don J van Meyel
Apr 05, 2016
Astrocyte development Astroglial map Notch Pointed Prospero Animals Astrocytes Cell Lineage Central Nervous System DNA-Binding Proteins Drosophila Proteins Drosophila melanogaster Excitatory Amino Acid Transporter 1 Excitatory Amino Acid Transporter 2 Gene Expression Regulation Developmental Nerve Tissue Proteins Neurogenesis Neuroglia Neuropil Nuclear Proteins Proto-Oncogene Proteins RNA Interference RNA Small Interfering Receptors Notch Transcription Factors
Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.
Debbie K Goode, Nadine Obier, MS Vijayabaskar, Michael Lie-A-Ling, Andrew J Lilly, Rebecca Hannah, Monika Lichtinger, Kiran Batta, Magdalena Florkowska, Rahima Patel, Mairi Challinor, Kirstie Wallace, Jane Gilmour, Salam A Assi, Pierre Cauchy, Maarten Hoogenkamp, David R Westhead, Georges Lacaud, Valerie Kouskoff, Berthold Göttgens, Constanze Bonifer
Mar 01, 2016
A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.
Walfred WC Tang, Sabine Dietmann, Naoko Irie, Harry G Leitch, Vasileios I Floros, Charles R Bradshaw, Jamie A Hackett, Patrick F Chinnery, M Azim Surani
Jun 04, 2015
Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder.
Aitana Perea-Gomez, Sigolène M Meilhac, Karolina Piotrowska-Nitsche, Dionne Gray, Jérôme Collignon, Magdalena Zernicka-Goetz
Jun 14, 2011
Polarization and orientation of retinal ganglion cells in vivo.
Flavio R Zolessi, Lucia Poggi, Christopher J Wilkinson, Chi-Bin Chien, William A Harris
Jun 16, 2011
Animals Animals Genetically Modified Axons Basement Membrane Cell Polarity Cells Cultured Embryo Nonmammalian Gene Expression Regulation Developmental Imaging Three-Dimensional Luminescent Proteins Microscopy Electron Transmission Morpholines Neuroepithelial Cells Retina Retinal Ganglion Cells Time Factors Zebrafish Zebrafish Proteins
Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis.
Samira Chabab, Fabienne Lescroart, Steffen Rulands, Navrita Mathiah, Benjamin D Simons, Cédric Blanpain
Dec 04, 2015
Miles J De Blasio, Maria Boije, Sarah L Kempster, Gordon CS Smith, D Stephen Charnock-Jones, Alice Denyer, Alexandra Hughes, FB Peter Wooding, Dominique Blache, Abigail L Fowden, Alison J Forhead
Oct 14, 2015
Animals Dose-Response Relationship Drug Female Fetal Therapies Fetus Gene Expression Regulation Developmental Infusions Intravenous Leptin Lung Lung Compliance Organogenesis Pregnancy Pulmonary Surfactant-Associated Protein B RNA Messenger Random Allocation Receptors Leptin Recombinant Proteins Sheep Total Lung Capacity
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