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Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding.
Paul Chappell, El Kahina Meziane, Michael Harrison, Łukasz Magiera, Clemens Hermann, Laura Mears, Antony G Wrobel, Charlotte Durant, Lise Lotte Nielsen, Søren Buus, Nicola Ternette, William Mwangi, Colin Butter, Venugopal Nair, Trudy Ahyee, Richard Duggleby, Alejandro Madrigal, Pietro Roversi, Susan M Lea, Jim Kaufman
Jun 15, 2015
HIV MHC Marek's disease avian chicken human immunology peptide repertoire Acquired Immunodeficiency Syndrome Adaptive Immunity Alleles Amino Acid Sequence Animals Antigen Presentation Binding Sites Cell Line Chickens Crystallography X-Ray Gene Expression Regulation HIV-1 Haplotypes Herpesvirus 2 Gallid Histocompatibility Antigens Class I Marek Disease Models Molecular Molecular Sequence Data Peptides Protein Binding Recombinant Proteins
The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek's Disease Virus Pathogenesis and Tumorigenesis.
Luca D Bertzbach, Clive A Tregaskes, Rebecca J Martin, Undine-Sophie Deumer, Lan Huynh, Ahmed M Kheimar, Andelé M Conradie, Jakob Trimpert, Jim Kaufman, Benedikt B Kaufer
Jul 14, 2022
The major histocompatibility complex (MHC) is crucial for appropriate immune responses against invading pathogens. Chickens possess a single predominantly-expressed class I molecule with strong associations between disease...
resistance SUSCEPTIBILITY B19 B9 major histocompatibility complex (MHC) B15 B21 Valo Animals Chickens Herpesvirus 2 Gallid Marek Disease Histocompatibility Antigens Major Histocompatibility Complex Haplotypes Disease Resistance Carcinogenesis
Published by: Frontiers in immunology
The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif.
Samer Halabi, Michael Ghosh, Stefan Stevanović, Hans-Georg Rammensee, Luca D Bertzbach, Benedikt B Kaufer, Martin C Moncrieffe, Bernd Kaspers, Sonja Härtle, Jim Kaufman
May 06, 2021