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We report full-length draft de novo genome assemblies for 16 widely used inbred mouse strains and find extensive strain-specific haplotype variation. We identify and characterize 2,567 regions on the current mouse reference...

Animals Animals Laboratory Chromosome Mapping Genetic Loci Genome Haplotypes Mice Mice Inbred BALB C Mice Inbred C3H Mice Inbred C57BL Mice Inbred CBA Mice Inbred DBA Mice Inbred NOD Mice Inbred Strains Molecular Sequence Annotation Phylogeny Polymorphism Single Nucleotide Species Specificity

Actomyosin Animals Cell Polarity Embryo Mammalian Mice Inbred C57BL Mice Inbred CBA Microscopy Confocal Myosin Type II Protein Kinase C Time-Lapse Imaging Type C Phospholipases

Aneuploidy Animals Blastocyst Cell Count Cell Lineage Chromosome Segregation Chromosomes Mammalian Embryo Implantation Female Fertilization in Vitro Humans In Situ Hybridization Fluorescence Male Mice Mice Inbred C57BL Mice Inbred CBA Mitosis Models Genetic Morpholines Mosaicism Protein Kinase Inhibitors Purines Zygote

Animals Blastocyst Body Patterning Ectoderm Embryonic Induction Endoderm Female Gene Expression Regulation Developmental Male Mice Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Pregnancy Viscera

Animals Bone Morphogenetic Protein 4 Bone Morphogenetic Protein 7 Bone Morphogenetic Protein Receptors Type II Cell Lineage Embryo Implantation Endoderm Female Gene Expression Regulation Developmental Male Mice Mice Inbred C57BL Mice Inbred CBA Signal Transduction Smad4 Protein

Mammalian embryogenesis is a paradigm of regulative development as mouse embryos show plasticity in the regulation of cell fate, cell number, and tissue morphogenesis. However, the mechanisms behind embryo plasticity remain...

Apoptosis Embryo Embryonic Stem Cells epithelial tissue Implantation lumenogenesis Morphogenesis Mouse embryogenesis regulative development size regulation Amnion Animals Apoptosis Cell Aggregation Embryo Mammalian Embryonic Stem Cells Female Mice Inbred C57BL Mice Inbred CBA Morphogenesis Organ Size Time Factors

BAF complex Chromatin remodelling epigenetics lineage specification Mouse embryo Pluripotency SMARCC1 Animals Blastocyst Cell Lineage Chromatin Assembly and Disassembly Embryonic Development Epigenesis Genetic Female Gene Expression Gene Expression Regulation Developmental Humans Male Methylation Mice Mice Inbred C57BL Mice Inbred CBA Protein-Arginine N-Methyltransferases Transcription Factors

Individual human epidermal cells differ in their self-renewal ability. To uncover the molecular basis for this heterogeneity, we performed genome-wide pooled RNA interference screens and identified genes conferring a clonal...

Adaptor Proteins Signal Transducing Animals Cell Cycle Proteins Cell Line Tumor Cell Proliferation Cells Cultured Epidermal Cells Female Gene Expression Regulation Humans Mice Inbred C57BL Mice Inbred CBA Mice Knockout Nuclear Proteins Stem Cells Trans-Activators Transcription Factors

The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs. Marker profiling shows...

Animals Biomarkers Blastocyst Inner Cell Mass Cell Differentiation Cell Line Cell Lineage Cell Proliferation Clone Cells Embryo Culture Techniques Embryo Implantation Embryonic Stem Cells Extracellular Signal-Regulated MAP Kinases Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Gestational Age Laminin Mice Mice 129 Strain Mice Inbred C57BL Mice Inbred CBA Phenotype Pluripotent Stem Cells Transcription Factors

Fertilization-induced cytoplasmic flows are a conserved feature of eggs in many species. However, until now the importance of cytoplasmic flows for the development of mammalian embryos has been unknown. Here, by combining a...

Actomyosin Animals Cell Survival cytoplasmic streaming Embryo Mammalian Female Fertilization Fertilization in Vitro Male Mice Mice Inbred C57BL Mice Inbred CBA Ovum Sperm-Ovum Interactions Spermatozoa Zygote

(+)-methamphetamine hydrochloride (PubChem CID: 66124) (−)-Cocaine hydrochloride (PubChem CID: 656832) haloperidol (PubChem CID: 3559) paroxetine hydrochloride hemihydrate (PubChem CID: 62878) reserpine (PubChem CID: 5770) Animals Central Nervous System Stimulants Circadian Clocks Circadian Rhythm Cocaine Disease Models Animal Female Huntington Disease Male Methamphetamine Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Motor Activity Paroxetine Receptors Dopamine Serotonin Serotonin Uptake Inhibitors Synaptic Transmission Vesicular Monoamine Transport Proteins

Actins Animals Benzamides Cell Proliferation Cells Cultured Dioxoles Epithelial Cells Female Flow Cytometry Gene Expression Profiling Green Fluorescent Proteins Interleukin Receptor Common gamma Subunit Mammary Glands Animal Mice Inbred C57BL Mice Inbred CBA Mice Inbred NOD Mice SCID Mice Transgenic Microscopy Fluorescence Myocytes Smooth Muscle Oligonucleotide Array Sequence Analysis Receptors Transforming Growth Factor beta Reverse Transcriptase Polymerase Chain Reaction Stem Cells

adenine Animals Cell Differentiation Cells Cultured Class I Phosphatidylinositol 3-Kinases Cytokines Diabetes mellitus Experimental Diabetes mellitus Type 1 Female Mice Mice Inbred C57BL Mice Inbred CBA Mice Inbred NOD Mice SCID Mice Transgenic Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Quinazolines T-Lymphocytes

ETS factors RBPJ Commitment DIFFERENTIATION Embryonic Stem Cell Epiblast gene regulatory network Pluripotency self-renewal Animals Basic Helix-Loop-Helix Transcription Factors Cell Differentiation Cell Line Cell Lineage Cell Self Renewal DNA-Binding Proteins Gene Knockout Techniques Gene Regulatory Networks Immunoglobulin J Recombination Signal Sequence-Binding Protein Mice Mice Inbred C57BL Mice Inbred CBA Nanog Homeobox Protein Neurons Pluripotent Stem Cells RNA Small Interfering T-Box Domain Proteins Transcription Factors

We have reported that the radical scavenger XJB-5-131 attenuates or reverses progression of the disease phenotype in the HdhQ(150/150) mouse, a slow onset model of HD. Here, we tested whether XJB-5-131 has beneficial effects in...

Age Factors Animals Behavior Animal Body Temperature Cyclic N-Oxides Disease Progression Female Huntington Disease Male Mice Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Motor Activity Phenotype Sex Factors

How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc's transcriptional roles at the epidermal differentiation...

Animals Epidermal Cells epidermis Feedback Physiological Female Homeostasis Keratinocytes Kruppel-Like Factor 4 Male Mice Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Primary Cell Culture Proto-Oncogene Proteins c-myc Repressor Proteins Sin3 Histone Deacetylase and Corepressor Complex Transcription Genetic

OBJECTIVE: Vascular smooth muscle cell (VSMC) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. The forkhead protein FOXO3a...

Muscle Smooth Vascular Cells Cultured Extracellular Matrix Myocytes Smooth Muscle Animals Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Humans Rats Wistar Carotid Artery Injuries Disease Models Animal Fibrosis Necrosis Signal Transduction Apoptosis Mutation Male Atherosclerosis Matrix Metalloproteinase 13 Transcriptional Activation Vascular Remodeling Forkhead Box Protein O3 Mice Knockout ApoE

BACKGROUND: Environmental enrichment (EE) in laboratory animals improves neurological function and motor/cognitive performance, and is proposed as a strategy for treating neurodegenerative diseases. EE has been investigated in...

Animal Husbandry Animals Circadian Rhythm Disease Models Animal Environment Design Female Genotype Humans Huntington Disease Male Mice Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Motor Activity Rotarod Performance Test Sex Factors Survival Analysis Swimming Trinucleotide Repeat Expansion