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We report full-length draft de novo genome assemblies for 16 widely used inbred mouse strains and find extensive strain-specific haplotype variation. We identify and characterize 2,567 regions on the current mouse reference...

Animals Animals Laboratory Chromosome Mapping Genetic Loci Genome Haplotypes Mice Mice Inbred BALB C Mice Inbred C3H Mice Inbred C57BL Mice Inbred CBA Mice Inbred DBA Mice Inbred NOD Mice Inbred Strains Molecular Sequence Annotation Phylogeny Polymorphism Single Nucleotide Species Specificity

X-chromosome inactivation is established during early development. In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic marks such as H3K27me3 is achieved by the early blastocyst...

Animals Blastocyst Inner Cell Mass Epigenesis Genetic Female Genes X-Linked Histones In Situ Hybridization Fluorescence Male Mice Mice Inbred C57BL Mice Inbred DBA Models Genetic Pregnancy RNA Long Noncoding Sequence Analysis RNA Single-Cell Analysis Transcription Factors X Chromosome Inactivation

To analyze the effect of levofloxacin-induced intestinal microbiota modifications on intestinal, joint, and systemic inflammation in the DBA/1 mice with spontaneous arthritis. The study included two groups of mice, one of which...

Mice Animals Levofloxacin Transcriptome Tumor Necrosis Factor-alpha Dysbiosis RNA Ribosomal 16S Mice Inbred DBA Spondylarthritis Inflammation Mice Inbred C57BL

aging Animals Cells Cultured Cellular Senescence DNA Methylation Epigenesis Genetic Epigenomics Gene Expression Profiling Gene Ontology Humans Mice Inbred C57BL Mice Inbred DBA Mice Transgenic Muscles Promoter Regions Genetic Single-Cell Analysis Stem Cells Transcriptome

The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3...

Animals Mice Inbred BALB C Mice Inbred C57BL Mice Inbred DBA Dogs Ferrets Humans Guinea Pigs Influenza A virus Communicable Diseases Emerging Zoonoses Dog Diseases United States Influenza Human Influenza A virus H3N2 Subtype Influenza A virus H3N8 Subtype

Dietary, pharmacological and genetic interventions can extend health- and lifespan in diverse mammalian species. DNA methylation has been implicated in mediating the beneficial effects of these interventions; methylation...

aging Animals Caloric Restriction DNA Methylation Databases Genetic Epigenesis Genetic Female Growth Substances Lipid Metabolism Liver longevity Male Mice Mice Inbred C57BL Mice Inbred DBA Mice Mutant Strains Receptor Fibroblast Growth Factor Type 3 Signal Transduction Sirolimus

Adipose Tissue Agouti-Related Protein Animals Body Weight Corticosterone Eating Gene Expression Regulation Glucocorticoids Hypothalamus Leptin Male Mice Inbred C57BL Mice Inbred DBA Mice Knockout Mice Transgenic obesity

Plvap Sox3 Lineage tracing Mice spermatogenic stem cells stem cell heterogeneity Testis Tissue homeostasis Adult Germline Stem Cells Animals Cell Lineage Cell Self Renewal Gene Expression Regulation Developmental Glial Cell Line-Derived Neurotrophic Factor Receptors Male Membrane Proteins Mice Inbred C57BL Mice Inbred DBA Mice Knockout Mitosis Models Biological Phenotype SOXB1 Transcription Factors Spermatogenesis Testis Time Factors

Continuous performance test Donepezil MOUSE Mouse strain differences Touchscreen operant chamber Animals Attention Cholinesterase Inhibitors Conditioning Operant Discrimination Learning discrimination Psychological Donepezil Drug Evaluation Preclinical Humans Indans Male Mice Mice Inbred C57BL Mice Inbred DBA Nootropic Agents Piperidines Psychomotor Performance Species Specificity Visual Perception