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BACKGROUND: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue...

Foetal programming Gestational diabetes Maternal obesity Metformin Sex differences White adipose tissue Adiposity Animals Animals Newborn Diabetes Gestational Female Male Metformin Mice Mice Inbred C57BL obesity Maternal Pregnancy prenatal exposure delayed effects Sex Factors

Maternal obesity and gestational diabetes mellitus (GDM) are associated with insulin resistance and health risks for mother and offspring. Obesity is also characterized by low-grade inflammation, which in turn, impacts insulin...

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Maternal obesity is a global problem that increases the risk of short- and long-term adverse outcomes for mother and child, many of which are linked to gestational diabetes mellitus. Effective treatments are essential to prevent...

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Fetus Mitochondria obesity obesogenic diet Placenta sex Animals Diet High-Fat Energy Metabolism Female Humans Lipid Metabolism Lipids Male Mice Mice Inbred C57BL obesity Maternal Oxidative Stress Placenta Pregnancy

Adult Age Factors Black People Diabetes Gestational Ethnicity Female Glucose Tolerance Test Humans Logistic Models Maternal Age Minority Groups obesity Maternal Odds Ratio Parity Patient Compliance Pregnancy Prenatal Care Risk Factors Social Class Ultrasonography Prenatal United Kingdom

The rise in prevalence of obesity in women of reproductive age in developed and developing countries might propagate intergenerational cycles of detrimental effects on metabolic health. Placental lipid metabolism is disrupted by...

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Biochemistry chemical biology developmental biology Fetal Heart heart metabolism lipidomics Maternal obesity MOUSE transcriptomics Animals Female Fetus Lipid Metabolism lipidomics Male Mice Myocardium obesity Maternal Pregnancy Transcriptome

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Animals Disease Models Animal Female Fetal Growth Retardation Male Mice Mice Inbred C57BL obesity Maternal Placenta Pregnancy Transcriptome

Adaptation Physiological Adult Body Mass Index Female Humans Male obesity Maternal Placenta Pregnancy Prospective Studies Pulsatile Flow Sex Factors Ultrasonography Doppler Umbilical Arteries Uterine Artery Vascular Resistance Young Adult

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The time period before, during and after pregnancy represents a unique opportunity for interventions to cultivate sustained healthy lifestyle behaviors to improve the metabolic health of mothers and their offspring. However, the...

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Hypothalamus Insulin Maternal obesity Neurogenesis Notch Animals Arcuate Nucleus of Hypothalamus Body Weight Brain Diet High-Fat Feeding Behavior Female Fetus Gene Expression Gene Expression Regulation Developmental Hypothalamus Insulin Insulin Resistance Male Maternal-Fetal Exchange Mice Mice Inbred C57BL Neural Stem Cells Neurons obesity obesity Maternal Pregnancy prenatal exposure delayed effects Weight Gain

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Obesity before and during pregnancy leads to reduced offspring cardiometabolic health. Here, we systematically reviewed animal experimental evidence of maternal obesity before and during pregnancy and offspring anthropometry and...

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