Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.
Stefania Carobbio,
Rachel M Hagen,
Christopher J Lelliott,
Marc Slawik,
Gema Medina-Gomez,
Chong-Yew Tan,
Audrey Sicard,
Helen J Atherton,
Nuria Barbarroja,
Mikael Bjursell,
Mohammad Bohlooly-Y,
Sam Virtue,
Antoinette Tuthill,
Etienne Lefai,
Martine Laville,
Tingting Wu,
Robert V Considine,
Hubert Vidal,
Dominique Langin,
Matej Oresic,
Francisco J Tinahones,
Jose Manuel Fernandez-Real,
Julian L Griffin,
Jaswinder K Sethi,
Miguel López,
Antonio Vidal-Puig
Feb 18, 2021
The epidemic of obesity imposes unprecedented challenges on human adipose tissue (WAT) storage capacity that may benefit from adaptive mechanisms to maintain adipocyte functionality. Here, we demonstrate that changes in the...