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Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
Sandra Blanco, Sabine Dietmann, Joana V Flores, Shobbir Hussain, Claudia Kutter, Peter Humphreys, Margus Lukk, Patrick Lombard, Lucas Treps, Martyna Popis, Stefanie Kellner, Sabine M Hölter, Lillian Garrett, Wolfgang Wurst, Lore Becker, Thomas Klopstock, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabĕ de Angelis, Ragnhildur T Káradóttir, Mark Helm, Jernej Ule, Joseph G Gleeson, Duncan T Odom, Michaela Frye
Jan 31, 2020
Mutations in the cytosine-5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities in mice and human. How post-transcriptional methylation contributes to the human disease is currently unknown. By...
Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity.
Bruno Sovran, Floor Hugenholtz, Marlies Elderman, Adriaan A Van Beek, Katrine Graversen, Myrte Huijskes, Mark V Boekschoten, Huub FJ Savelkoul, Paul De Vos, Jan Dekker, Jerry M Wells
Jul 16, 2019
Aging significantly increases the vulnerability to gastrointestinal (GI) disorders but there are few studies investigating the key factors in aging that affect the GI tract. To address this knowledge gap, we used 10-week- and...