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Results: 36
Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.
Cynthia Tallant, Erica Valentini, Oleg Fedorov, Lois Overvoorde, Fleur M Ferguson, Panagis Filippakopoulos, Dmitri I Svergun, Stefan Knapp, Alessio Ciulli
Feb 03, 2015
SSBP1-Disease Update
Neringa Jurkute, Fabiana D'Esposito, Anthony G Robson, Robert DS Pitceathly, Francesca Cordeiro, F Lucy Raymond, Anthony T Moore, Michel Michaelides, Patrick Yu-Wai-Man, Andrew R Webster, Gavin Arno, Genomics England Research Consortium
Jan 28, 2022
Adolescent Amino Acid Sequence Child Preschool DNA Mitochondrial DNA-Binding Proteins Electroretinography Female Genes Recessive Genotyping Techniques Humans Male Middle Aged Mitochondrial Diseases Mitochondrial Proteins Molecular Conformation Molecular Sequence Data Mutation Missense Optic Atrophy Pedigree Penetrance Protein Stability Protein Structure Quaternary Retinal Dystrophies whole genome sequencing
Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.
Patricia Paracuellos, Sebastian Kalamajski, Arkadiusz Bonna, Dominique Bihan, Richard W Farndale, Erhard Hohenester
Jan 24, 2018
The small leucine-rich proteoglycans (SLRPs) are important regulators of extracellular matrix assembly and cell signalling. We have determined crystal structures at ~2.2Å resolution of human fibromodulin and chondroadherin, two...
Collagen Leucine-rich repeat X-ray crystallography Amino Acid Sequence Crystallography X-Ray Cystine Extracellular Matrix Proteins fibromodulin HEK293 Cells Humans Hydrophobic and Hydrophilic Interactions Models Molecular Protein Binding Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Structure Quaternary Solutions
CRIB effector disorder
CRIB effectors Intrinsically Disordered Proteins Protein Conformation small G-proteins Animals GTP Phosphohydrolases GTP-Binding Proteins Gene Expression Regulation Humans Hydrophobic and Hydrophilic Interactions Membrane Proteins Nonlinear dynamics Polylysine Protein Binding Protein Domains Protein Structure Quaternary Signal Transduction Static Electricity Tumor Suppressor Proteins cdc42 GTP-Binding Protein rac1 GTP-Binding Protein
Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.
Erwin De Genst, Dimitri Y Chirgadze, Fabrice AC Klein, David C Butler, Dijana Matak-Vinković, Yvon Trottier, James S Huston, Anne Messer, Christopher M Dobson
May 27, 2015
Huntington's disease aggregation inhibition Amyloid prefibrillar intermediates single-chain Fv antibody Amyloid Chemical Phenomena Crystallography X-Ray Humans Huntingtin Protein Magnetic Resonance Spectroscopy Models Molecular Nerve Tissue Proteins Protein Binding Protein Multimerization Protein Structure Quaternary Single-Chain Antibodies
Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family
The tegumental allergen-like (TAL) proteins from Schistosoma mansoni are part of a family of calcium binding proteins found only in parasitic flatworms. These proteins have attracted interest as potential drug or vaccine...
In situ structure and assembly of the multidrug efflux pump AcrAB-TolC.
Xiaodong Shi, Muyuan Chen, Zhili Yu, James M Bell, Hans Wang, Isaac Forrester, Heather Villarreal, Joanita Jakana, Dijun Du, Ben F Luisi, Steven J Ludtke, Zhao Wang
Jun 13, 2019
Anti-Bacterial Agents Bacterial Outer Membrane Proteins Carrier Proteins Cryoelectron Microscopy Drug Resistance Multiple Bacterial Electron Microscope Tomography Escherichia coli Escherichia coli Proteins Intravital Microscopy Lipoproteins Membrane Transport Proteins Multidrug Resistance-Associated Proteins Peptidoglycan Periplasm Protein Binding Protein Structure Quaternary
Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.
G Brent Dawe, Md Fahim Kadir, Raminta Venskutonytė, Amanda M Perozzo, Yuhao Yan, Ryan PD Alexander, Camilo Navarrete, Eduardo A Santander, Marika Arsenault, Christian Fuentes, Mark RP Aurousseau, Karla Frydenvang, Nelson P Barrera, Jette S Kastrup, J Michael Edwardson, Derek Bowie
Apr 16, 2019
Neurotransmitter-gated ion channels are allosteric proteins that switch on and off in response to agonist binding. Most studies have focused on the agonist-bound, activated channel while assigning a lesser role to the apo or...
X-ray crystallography Alternative Splicing Atomic force microscopy channel gating Electrophysiology Ion channel ionotropic glutamate receptor Patch clamp protein conformations synapse Allosteric Regulation Allosteric Site Alternative Splicing Animals cerebellum Cryoelectron Microscopy Crystallography X-Ray HEK293 Cells Humans Ion Channel Gating Membrane Proteins Mice Microscopy Atomic Force Patch-Clamp Techniques Protein Domains Protein Isoforms Protein Structure Quaternary Protein Structure Tertiary Purkinje Cells Receptors AMPA
Joanna R Watson, Helen M Fox, Daniel Nietlispach, Jennifer L Gallop, Darerca Owen, Helen R Mott
May 05, 2016
BAR domain Cdc42 CIP4 FBP17 TOCA1 WASP actin Endocytosis Nuclear Magnetic Resonance (NMR) Protein-Protein Interaction Animals Carrier Proteins Fatty Acid-Binding Proteins Humans Monomeric GTP-Binding Proteins Protein Binding Protein Domains Protein Structure Quaternary Wiskott-Aldrich Syndrome Protein Neuronal Xenopus Proteins Xenopus laevis
Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55.
BTB–Kelch E3 ubiquitin ligase X-ray crystallography immunosuppression innate immunity isothermal titration calorimetry (ITC) Poxvirus Protein Structure structure-function viral immunology Amino Acid Substitution Cullin Proteins HEK293 Cells Humans Multiprotein Complexes Mutation Missense Protein Domains Protein Structure Quaternary Proteolysis Ubiquitination Vaccinia vaccinia virus Viral Proteins
The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state.
Sotiria Tavoulari, Chancievan Thangaratnarajah, Vasiliki Mavridou, Michael E Harbour, Jean-Claude Martinou, Edmund RS Kunji
Apr 05, 2019
Mitochondria oligomeric state Protein complex Pyruvate transport proteins Anion Transport Proteins Gene Expression Regulation Fungal Mitochondrial Membrane Transport Proteins Monocarboxylic Acid Transporters Multiprotein Complexes Organisms Genetically Modified Protein Multimerization Protein Structure Quaternary Pyruvic Acid Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Structure-Activity Relationship Temperature
Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner.
The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein...
Tcf Armadillo Repeat BETA-CATENIN Fuzzy Complex intrinsic disorder Intrinsically Disordered Protein Protein Folding protein-protein interactions repeat protein tandem-repeat protein Crystallography X-Ray Humans Intrinsically Disordered Proteins Mutagenesis Site-Directed Protein Structure Quaternary Transcription Factor 7-Like 2 Protein beta Catenin
Potential regulatory interactions of Escherichia coli RraA protein with DEAD-box helicases.
Members of the DEAD-box family of RNA helicases contribute to virtually every aspect of RNA metabolism, in organisms from all domains of life. Many of these helicases are constituents of multicomponent assemblies, and their...
Analytical Ultracentrifugation protein-protein interactions RNA helicase RNA-binding protein Regulator of Ribonuclease Activity A RhlB RraA SrmB X-ray crystallography Crystallography X-Ray DEAD-box RNA Helicases Endoribonucleases Escherichia coli Escherichia coli Proteins Models Molecular Protein Binding Protein Structure Quaternary Protein Structure Tertiary
Evolution of interface binding strengths in simplified model of protein quaternary structure.
The self-assembly of proteins into protein quaternary structures is of fundamental importance to many biological processes, and protein misassembly is responsible for a wide range of proteopathic diseases. In recent years...
Protein flexibility facilitates quaternary structure assembly and evolution.
The intrinsic flexibility of proteins allows them to undergo large conformational fluctuations in solution or upon interaction with other molecules. Proteins also commonly assemble into complexes with diverse quaternary...
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.
Ahmed-Noor A Agip, James N Blaza, Hannah R Bridges, Carlo Viscomi, Shaun Rawson, Stephen P Muench, Judy Hirst
Aug 15, 2018
Complex I (NADH:ubiquinone oxidoreductase) uses the reducing potential of NADH to drive protons across the energy-transducing inner membrane and power oxidative phosphorylation in mammalian mitochondria. Recent cryo-EM analyses...
Structural model of FeoB, the iron transporter from Pseudomonas aeruginosa, predicts a cysteine lined, GTP-gated pore.
Saeed Seyedmohammad, Natalia Alveal Fuentealba, Robert AJ Marriott, Tom A Goetze, J Michael Edwardson, Nelson P Barrera, Henrietta Venter
Mar 02, 2016
Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure.
James H Felce, Sarah L Latty, Rachel G Knox, Susan R Mattick, Yuan Lui, Steven F Lee, David Klenerman, Simon J Davis
May 10, 2018
The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors....
The fifth adaptor protein complex.
Jennifer Hirst, Lael D Barlow, Gabriel Casey Francisco, Daniela A Sahlender, Matthew NJ Seaman, Joel B Dacks, Margaret S Robinson
Jan 24, 2018
Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes. We report the...
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