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Structural and functional analysis of four non-coding Y RNAs from Chinese hamster cells
Quirino Alves de Lima Neto, Francisco Ferreira Duarte Junior, Paulo Sérgio Alves Bueno, Flavio Augusto Vicente Seixas, Madzia Pauline Kowalski, Eyemen Kheir, Torsten Krude, Maria Aparecida Fernandez
Sep 29, 2016
BACKGROUND: The genes coding for Y RNAs are evolutionarily conserved in vertebrates. These non-coding RNAs are essential for the initiation of chromosomal DNA replication in vertebrate cells. However thus far, no information is...
RNAcentral
AI Petrov, SJE Kay, I Kalvari, KL Howe, KA Gray, EA Bruford, PJ Kersey, G Cochrane, RD Finn, A Bateman, A Kozomara, S Griffiths-Jones, A Frankish, CW Zwieb, BY Lau, KP Williams, PP Chan, TM Lowe, JJ Cannone, RR Gutell, MA Machnicka, JM Bujnicki, M Yoshihama, N Kenmochi, B Chai, JR Cole, M Szymanski, WM Karlowski, V Wood, E Huala, TZ Berardini, Y Zhao, R Chen, W Zhu, MD Paraskevopoulou, IS Vlachos, AG Hatzigeorgiou, L Ma, Z Zhang, J Puetz, PF Stadler, D McDonald, S Basu, P Fey, SR Engel, JM Cherry, PJ Volders, P Mestdagh, J Wower, M Clark, XC Quek, ME Dinger
Jul 31, 2017
A novel neuroprotective therapy for Parkinson's disease using a viral noncoding RNA that protects mitochondrial complex I activity.
Wei-Li Kuan, Emma Poole, Michael Fletcher, Sharon Karniely, Pam Tyers, Mark Wills, Roger A Barker, John H Sinclair
Nov 16, 2017
Parkinson's disease (PD) is a neurodegenerative disorder that results in the loss of nigrostriatal dopamine neurons. The etiology of this cell loss is unknown, but it involves abnormalities in mitochondrial function. In this...
Animals Cell Death Cell Line Cytomegalovirus Disease Models Animal Dopaminergic Neurons Electron Transport Complex I Enzyme Activation HEK293 Cells Humans Injections Intravenous Male Mitochondria Neuroprotective Agents Neurotoxins Parkinson Disease Peptides RNA transport RNA Untranslated RNA Viral Rats Rats Sprague-Dawley Substantia Nigra
High-resolution transcription atlas of the mitotic cell cycle in budding yeast.
Marina V Granovskaia, Lars J Jensen, Matthew E Ritchie, Joern Toedling, Ye Ning, Peer Bork, Wolfgang Huber, Lars M Steinmetz
Jun 17, 2011
Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus.
Christopher A Odhams, Andrea Cortini, Lingyan Chen, Amy L Roberts, Ana Viñuela, Alfonso Buil, Kerrin S Small, Emmanouil T Dermitzakis, David L Morris, Timothy J Vyse, Deborah S Cunninghame Graham
Nov 26, 2019
Studies attempting to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have predominantly employed microarrays to quantify gene-expression. RNA-Seq has the potential to discover a more...
Alternative Splicing Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor Chromosome Mapping Female Gene Expression Regulation Genetic Predisposition to Disease Genome-Wide Association Study Haplotypes Humans Lupus Erythematosus Systemic Male Polymorphism Single Nucleotide Quantitative Trait Loci RNA Untranslated T Cell Transcription Factor 1
Non-coding RNAs underlie genetic predisposition to breast cancer.
Mahdi Moradi Marjaneh, Jonathan Beesley, Tracy A O'Mara, Pamela Mukhopadhyay, Lambros T Koufariotis, Stephen Kazakoff, Nehal Hussein, Laura Fachal, Nenad Bartonicek, Kristine M Hillman, Susanne Kaufmann, Haran Sivakumaran, Chanel E Smart, Amy E McCart Reed, Kaltin Ferguson, Jodi M Saunus, Sunil R Lakhani, Daniel R Barnes, Antonis C Antoniou, Marcel E Dinger, Nicola Waddell, Douglas F Easton, Alison M Dunning, Georgia Chenevix-Trench, Stacey L Edwards, Juliet D French
Dec 16, 2019
BACKGROUND: Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements such as enhancers and promoters. However, the...
Inhibition of profibrotic microRNA-21 affects platelets and their releasate.
Temo Barwari, Seda Eminaga, Ursula Mayr, Ruifang Lu, Paul C Armstrong, Melissa V Chan, Mahnaz Sahraei, Marta Fernández-Fuertes, Thomas Moreau, Javier Barallobre-Barreiro, Marc Lynch, Xiaoke Yin, Christian Schulte, Ferheen Baig, Raimund Pechlaner, Sarah R Langley, Anna Zampetaki, Peter Santer, Martin Weger, Roberto Plasenzotti, Markus Schosserer, Johannes Grillari, Stefan Kiechl, Johann Willeit, Ajay M Shah, Cedric Ghevaert, Timothy D Warner, Carlos Fernández-Hernando, Yajaira Suárez, Manuel Mayr
Jan 09, 2019
Fibrosis is a major contributor to organ disease for which no specific therapy is available. MicroRNA-21 (miR-21) has been implicated in the fibrogenetic response, and inhibitors of miR-21 are currently undergoing clinical...
Cardiology Cell Biology Fibrosis NONCODING RNAS platelets Aged Aged 80 and over Animals Blood Platelets Clinical Trials as Topic Extracellular Matrix Female FIBROBLASTS Fibrosis Humans Male Mice Mice Inbred C57BL MicroRNAs Middle Aged Myocardium Prospective Studies Proteomics RNA Untranslated Transforming Growth Factor beta1 Wiskott-Aldrich Syndrome Protein
ncRNAseq
Despite their abundance, mid-sized RNAs (30-300 nt) have not been extensively studied by high-throughput sequencing, mostly due to selective loss in library preparation. The authors propose simple and inexpensive modifications...
Quantitative profiling of peptides from RNAs classified as noncoding.
Sudhakaran Prabakaran, Martin Hemberg, Ruchi Chauhan, Dominic Winter, Ry Y Tweedie-Cullen, Christian Dittrich, Elizabeth Hong, Jeremy Gunawardena, Hanno Steen, Gabriel Kreiman, Judith A Steen
May 09, 2018
Only a small fraction of the mammalian genome codes for messenger RNAs destined to be translated into proteins, and it is generally assumed that a large portion of transcribed sequences--including introns and several classes of...
Clonally stable Vκ allelic choice instructs Igκ repertoire.
Rena Levin-Klein, Shira Fraenkel, Michal Lichtenstein, Louise S Matheson, Osnat Bartok, Yuval Nevo, Sebastian Kadener, Anne E Corcoran, Howard Cedar, Yehudit Bergman
Jun 24, 2019
Although much has been done to understand how rearrangement of the Igκ locus is regulated during B-cell development, little is known about the way the variable (V) segments themselves are selected. Here we show, using B6/Cast...
Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans.
Clive J Petry, Ken K Ong, Bryan J Barratt, Diane Wingate, Heather J Cordell, Susan M Ring, Marcus E Pembrey, Wolf Reik, John A Todd, David B Dunger, ALSPAC Study Team
Jun 16, 2011
Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration
Chao Yang, Xu Wang, Jianying Wang, Xuejie Wang, Weitao Chen, Na Lu, Symeon Siniossoglou, Zhongping Yao, Kai Liu
Dec 16, 2019
DGAT1 DGAT2 Lipin1 Axon regeneration glycerolipid phospholipid Retinal ganglion cell triglyceride Animals Axons Axotomy Cells Cultured Diacylglycerol O-Acyltransferase Female Gene Knock-In Techniques Hydrolysis Male Mice Mice Transgenic Nerve Regeneration Optic Nerve Injuries PTEN Phosphohydrolase Phosphatidate Phosphatase Phospholipids Primary Cell Culture RNA Untranslated Retinal Ganglion Cells Rod Opsins Triglycerides
Targeting non-coding RNA family members with artificial endonuclease XNAzymes.
Non-coding RNAs (ncRNAs) offer a wealth of therapeutic targets for a range of diseases. However, secondary structures and high similarity within sequence families make specific knockdown challenging. Here, we engineer a series...
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.
Eleni Zengini, Konstantinos Hatzikotoulas, Ioanna Tachmazidou, Julia Steinberg, Fernando P Hartwig, Lorraine Southam, Sophie Hackinger, Cindy G Boer, Unnur Styrkarsdottir, Arthur Gilly, Daniel Suveges, Britt Killian, Thorvaldur Ingvarsson, Helgi Jonsson, George C Babis, Andrew McCaskie, Andre G Uitterlinden, Joyce BJ van Meurs, Unnur Thorsteinsdottir, Kari Stefansson, George Davey Smith, Jeremy M Wilkinson, Eleftheria Zeggini
May 03, 2018
Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants from the UK Biobank resource. After...
A guide to naming human non-coding RNA genes.
Ruth L Seal, Ling-Ling Chen, Sam Griffiths-Jones, Todd M Lowe, Michael B Mathews, Dawn O'Reilly, Andrew J Pierce, Peter F Stadler, Igor Ulitsky, Sandra L Wolin, Elspeth A Bruford
Apr 20, 2020
Research on non-coding RNA (ncRNA) is a rapidly expanding field. Providing an official gene symbol and name to ncRNA genes brings order to otherwise potential chaos as it allows unambiguous communication about each gene. The...
Mechanistic insights into non-coding Y RNA processing.
Martina Billmeier, Darrell Green, Adam E Hall, Carly Turnbull, Archana Singh, Ping Xu, Simon Moxon, Tamas Dalmay
May 01, 2022
Y RNAs (84-112 nt) are non-coding RNAs transcribed by RNA polymerase III and are characterized by a distinctive secondary structure. Human Y RNAs interact with the autoimmune proteins SSB and RO60 that together form a...
Transgenerational inheritance
Heritability has traditionally been thought to be a characteristic feature of the genetic material of an organism-notably, its DNA. However, it is now clear that inheritance not based on DNA sequence exists in multiple...
Detecting and comparing non-coding RNAs in the high-throughput era.
In recent years there has been a growing interest in the field of non-coding RNA. This surge is a direct consequence of the discovery of a huge number of new non-coding genes and of the finding that many of these transcripts are...
RNAcentral 2021
RNAcentral Consortium
Feb 12, 2021
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also...
Deep learning predicts short non-coding RNA functions from only raw sequence data.
Small non-coding RNAs (ncRNAs) are short non-coding sequences involved in gene regulation in many biological processes and diseases. The lack of a complete comprehension of their biological functionality, especially in a...
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